| Title |
Universal Sharing Patterns in Proteomes and Evolution of Protein Fold Architecture and Life
|
|---|---|
| Published in |
Journal of Molecular Evolution, April 2005
|
| DOI | 10.1007/s00239-004-0221-6 |
| Pubmed ID | |
| Authors |
Gustavo Caetano-Anollés, Derek Caetano-Anollés |
| Abstract |
Protein evolution is imprinted in both the sequence and the structure of evolutionary building blocks known as protein domains. These domains share a common ancestry and can be unified into a comparatively small set of folding architectures, the protein folds. We have traced the distribution of protein folds between and within proteomes belonging to Eukarya, Archaea, and Bacteria along the branches of a universal phylogeny of protein architecture. This tree was reconstructed from global fold-usage statistics derived from a structural census of proteomes. We found that folds shared by the three organismal domains were placed almost exclusively at the base of the rooted tree and that there were marked heterogeneities in fold distribution and clear evolutionary patterns related to protein architecture and organismal diversification. These include a relative timing for the emergence of prokaryotes, congruent episodes of architectural loss and diversification in Archaea and Bacteria, and a late and quite massive rise of architectural novelties in Eukarya perhaps linked to multicellularity. |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 5% |
| Chile | 1 | 3% |
| Italy | 1 | 3% |
| Mexico | 1 | 3% |
| Spain | 1 | 3% |
| Unknown | 31 | 84% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 27% |
| Student > Ph. D. Student | 9 | 24% |
| Professor | 4 | 11% |
| Professor > Associate Professor | 3 | 8% |
| Student > Master | 3 | 8% |
| Other | 7 | 19% |
| Unknown | 1 | 3% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 54% |
| Biochemistry, Genetics and Molecular Biology | 8 | 22% |
| Computer Science | 4 | 11% |
| Mathematics | 1 | 3% |
| Philosophy | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 1 | 3% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2015.
All research outputs
#5,864,294
of 22,776,824 outputs
Outputs from Journal of Molecular Evolution
#356
of 1,438 outputs
Outputs of similar age
#17,928
of 59,980 outputs
Outputs of similar age from Journal of Molecular Evolution
#1
of 6 outputs
Altmetric has tracked 22,776,824 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 1,438 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 59,980 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them