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The protein folding ‘speed limit’

Overview of attention for article published in Current Opinion in Structural Biology, February 2004
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
patent
5 patents
wikipedia
9 Wikipedia pages

Citations

dimensions_citation
767 Dimensions

Readers on

mendeley
688 Mendeley
citeulike
13 CiteULike
connotea
2 Connotea
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Title
The protein folding ‘speed limit’
Published in
Current Opinion in Structural Biology, February 2004
DOI 10.1016/j.sbi.2004.01.013
Pubmed ID
Authors

Jan Kubelka, James Hofrichter, William A Eaton

Abstract

How fast can a protein possibly fold? This question has stimulated experimentalists to seek fast folding proteins and to engineer them to fold even faster. Proteins folding at or near the speed limit are prime candidates for all-atom molecular dynamics simulations. They may also have no free energy barrier, allowing the direct observation of intermediate structures on the pathways from the unfolded to the folded state. Both experimental and theoretical approaches predict a speed limit of approximately N/100micros for a generic N-residue single-domain protein, with alpha proteins folding faster than beta or alphabeta. The predicted limits suggest that most known ultrafast folding proteins can be engineered to fold more than ten times faster.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 688 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 24 3%
Germany 7 1%
Italy 4 <1%
United Kingdom 3 <1%
Czechia 3 <1%
France 2 <1%
Mexico 2 <1%
Japan 2 <1%
Denmark 2 <1%
Other 16 2%
Unknown 623 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 199 29%
Researcher 134 19%
Student > Master 63 9%
Professor > Associate Professor 53 8%
Student > Bachelor 46 7%
Other 137 20%
Unknown 56 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 177 26%
Chemistry 159 23%
Physics and Astronomy 99 14%
Biochemistry, Genetics and Molecular Biology 93 14%
Engineering 23 3%
Other 64 9%
Unknown 73 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2023.
All research outputs
#1,980,744
of 25,374,917 outputs
Outputs from Current Opinion in Structural Biology
#71
of 2,067 outputs
Outputs of similar age
#4,143
of 146,672 outputs
Outputs of similar age from Current Opinion in Structural Biology
#1
of 13 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,067 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 146,672 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.