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Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells

Overview of attention for article published in Cell Death & Disease, January 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Average Attention Score compared to outputs of the same age and source

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1 news outlet
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1 X user

Citations

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113 Dimensions

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105 Mendeley
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Title
Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells
Published in
Cell Death & Disease, January 2015
DOI 10.1038/cddis.2014.548
Pubmed ID
Authors

S Saveljeva, S L Mc Laughlin, P Vandenabeele, A Samali, M J M Bertrand

Abstract

Endoplasmic reticulum (ER) stress-induced cellular dysfunction and death is associated with several human diseases. It has been widely reported that ER stress kills through activation of the intrinsic mitochondrial apoptotic pathway. Here we demonstrate that ER stress can also induce necroptosis, an receptor-interacting protein kinase 1 (RIPK1)/RIPK3/mixed lineage kinase domain-like protein (MLKL)-dependent form of necrosis. Remarkably, we observed that necroptosis induced by various ER stressors in L929 cells is dependent on tumor necrosis factor receptor 1 (TNFR1), but occurs independently of autocrine TNF or lymphotoxin α production. Moreover, we found that repression of either TNFR1, RIPK1 or MLKL did not protect the cells from death but instead allowed a switch to ER stress-induced apoptosis. Interestingly, while caspase inhibition was sufficient to protect TNFR1- or MLKL-deficient cells from death, rescue of the RIPK1-deficient cells additionally required RIPK3 depletion, indicating a switch back to RIPK3-dependent necroptosis in caspase-inhibited conditions. The finding that ER stress also induces necroptosis may open new therapeutic opportunities for the treatment of pathologies resulting from unresolved ER stress.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 2 2%
United Kingdom 1 <1%
Unknown 102 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 24%
Researcher 17 16%
Student > Master 15 14%
Student > Bachelor 12 11%
Student > Doctoral Student 7 7%
Other 17 16%
Unknown 12 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 30 29%
Agricultural and Biological Sciences 26 25%
Medicine and Dentistry 12 11%
Immunology and Microbiology 7 7%
Neuroscience 6 6%
Other 10 10%
Unknown 14 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2015.
All research outputs
#3,191,998
of 22,776,824 outputs
Outputs from Cell Death & Disease
#1,046
of 6,427 outputs
Outputs of similar age
#47,464
of 352,269 outputs
Outputs of similar age from Cell Death & Disease
#62
of 111 outputs
Altmetric has tracked 22,776,824 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,427 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,269 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 111 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.