| Title |
The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer’s Disease
|
|---|---|
| Published in |
Molecular Neurobiology, January 2015
|
| DOI | 10.1007/s12035-014-9063-4 |
| Pubmed ID | |
| Authors |
Yanuar Alan Sulistio, Klaus Heese |
| Abstract |
One of the shared hallmarks of neurodegenerative diseases is the accumulation of misfolded proteins. Therefore, it is suspected that normal proteostasis is crucial for neuronal survival in the brain and that the malfunction of this mechanism may be the underlying cause of neurodegenerative diseases. The accumulation of amyloid plaques (APs) composed of amyloid-beta peptide (Aβ) aggregates and neurofibrillary tangles (NFTs) composed of misfolded Tau proteins are the defining pathological markers of Alzheimer's disease (AD). The accumulation of these proteins indicates a faulty protein quality control in the AD brain. An impaired ubiquitin-proteasome system (UPS) could lead to negative consequences for protein regulation, including loss of function. Another pivotal mechanism for the prevention of misfolded protein accumulation is the utilization of molecular chaperones. Molecular chaperones, such as heat shock proteins (HSPs) and FK506-binding proteins (FKBPs), are highly involved in protein regulation to ensure proper folding and normal function. In this review, we elaborate on the molecular basis of AD pathophysiology using recent data, with a particular focus on the role of the UPS and molecular chaperones as the defensive mechanism against misfolded proteins that have prion-like properties. In addition, we propose a rational therapy approach based on this mechanism. |
Mendeley readers
The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 111 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 26% |
| Researcher | 17 | 15% |
| Student > Master | 14 | 12% |
| Student > Bachelor | 12 | 11% |
| Other | 7 | 6% |
| Other | 18 | 16% |
| Unknown | 16 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 23% |
| Biochemistry, Genetics and Molecular Biology | 26 | 23% |
| Neuroscience | 13 | 12% |
| Medicine and Dentistry | 8 | 7% |
| Chemistry | 6 | 5% |
| Other | 13 | 12% |
| Unknown | 21 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2024.
All research outputs
#3,103,574
of 24,040,389 outputs
Outputs from Molecular Neurobiology
#460
of 3,623 outputs
Outputs of similar age
#43,614
of 360,015 outputs
Outputs of similar age from Molecular Neurobiology
#7
of 64 outputs
Altmetric has tracked 24,040,389 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,623 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done well, scoring higher than 86% of its peers.
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We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.