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Alteration of Leukocyte Count Correlates With Increased Pulmonary Vascular Permeability and Decreased PaO2

Overview of attention for article published in Journal of burn care & research, January 2015
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Title
Alteration of Leukocyte Count Correlates With Increased Pulmonary Vascular Permeability and Decreased PaO2
Published in
Journal of burn care & research, January 2015
DOI 10.1097/bcr.0000000000000211
Pubmed ID
Authors

Joakim Johansson, Ingrid Steinvall, Heiko Herwald, Lennart Lindbom, Folke Sjöberg

Abstract

Leukocytes are activated systemically and their numbers increase soon after a burn followed by a rapid decline to low normal or subnormal levels, possibly by increased extravasation. Experimental data support that an important target for such extravasation is the lungs and that leukocytes when they adhere to endothelial cells cause an increase in vascular permeability. The authors investigated a possible relation between early increased pulmonary vascular permeability or a decreased PaO2:FiO2-ratio and the dynamic change in concentration of blood leukocytes after a burn. This is a prospective, exploratory, single-center study. The authors measured the dynamic changes of leukocytes in blood starting early after the burn, pulmonary vascular permeability index by thermodilution, and PaO2:FiO2-ratios in 20 patients during the first 21 days after a major burn (>20% TBSA%). Median TBSA was 40% interquartile range (IQR, 25-52) and full thickness burn 28% (IQR, 2-39). There was a correlation between the early (<24 hours) alteration in white blood cell count and both early increased pulmonary vascular permeability (r = .63, P = .004) and the decreased oxygenation index defined as PaO2:FiO2 < 27 kPa (P = .004). The authors have documented a correlation between dynamic change of blood leukocytes and pulmonary failure early after burns.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 25%
Lecturer > Senior Lecturer 1 8%
Student > Doctoral Student 1 8%
Other 1 8%
Student > Ph. D. Student 1 8%
Other 1 8%
Unknown 4 33%
Readers by discipline Count As %
Medicine and Dentistry 6 50%
Immunology and Microbiology 1 8%
Nursing and Health Professions 1 8%
Unknown 4 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2015.
All research outputs
#19,944,091
of 25,373,627 outputs
Outputs from Journal of burn care & research
#1,238
of 2,101 outputs
Outputs of similar age
#252,325
of 359,515 outputs
Outputs of similar age from Journal of burn care & research
#60
of 134 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,101 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
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We're also able to compare this research output to 134 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.