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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model
|
|---|---|
| Published in |
Nutrients, January 2015
|
| DOI | 10.3390/nu7010306 |
| Pubmed ID | |
| Authors |
António M. Santos, Teresa Lopes, Mónica Oleastro, Inês Vale Gato, Pauline Floch, Lucie Benejat, Paula Chaves, Teresa Pereira, Elsa Seixas, Jorge Machado, António S. Guerreiro |
| Abstract |
Helicobacter pylori (H. pylori) infection triggers a sequence of gastric alterations starting with an inflammation of the gastric mucosa that, in some cases, evolves to gastric cancer. Efficient vaccination has not been achieved, thus it is essential to find alternative therapies, particularly in the nutritional field. The current study evaluated whether curcumin could attenuate inflammation of the gastric mucosa due to H. pylori infection. Twenty-eight C57BL/6 mice, were inoculated with the H. pylori SS1 strain; ten non-infected mice were used as controls. H. pylori infection in live mice was followed-up using a modified 13C-Urea Breath Test (13C-UBT) and quantitative real-time polymerase chain reaction (PCR). Histologically confirmed, gastritis was observed in 42% of infected non-treated mice at both 6 and 18 weeks post-infection. These mice showed an up-regulation of the expression of inflammatory cytokines and chemokines, as well as of toll-like receptors (TLRs) and MyD88, at both time points. Treatment with curcumin decreased the expression of all these mediators. No inflammation was observed by histology in this group. Curcumin treatment exerted a significant anti-inflammatory effect in H. pylori-infected mucosa, pointing to the promising role of a nutritional approach in the prevention of H. pylori induced deleterious inflammation while the eradication or prevention of colonization by effective vaccine is not available. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 79 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 19% |
| Researcher | 13 | 16% |
| Student > Ph. D. Student | 10 | 12% |
| Student > Bachelor | 6 | 7% |
| Student > Postgraduate | 6 | 7% |
| Other | 8 | 10% |
| Unknown | 23 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 12% |
| Agricultural and Biological Sciences | 9 | 11% |
| Immunology and Microbiology | 8 | 10% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Other | 9 | 11% |
| Unknown | 27 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2015.
All research outputs
#13,901,936
of 23,577,654 outputs
Outputs from Nutrients
#11,454
of 18,570 outputs
Outputs of similar age
#177,160
of 355,926 outputs
Outputs of similar age from Nutrients
#60
of 99 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 18,570 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.0. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 355,926 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.