| Title |
Risk of cancer incidence before the age of 15 years after exposure to ionising radiation from computed tomography: results from a German cohort study
|
|---|---|
| Published in |
Radiation and Environmental Biophysics, January 2015
|
| DOI | 10.1007/s00411-014-0580-3 |
| Pubmed ID | |
| Authors |
L. Krille, S. Dreger, R. Schindel, T. Albrecht, M. Asmussen, J. Barkhausen, J. D. Berthold, A. Chavan, C. Claussen, M. Forsting, E. A. L. Gianicolo, K. Jablonka, A. Jahnen, M. Langer, M. Laniado, J. Lotz, H. J. Mentzel, A. Queißer-Wahrendorf, O. Rompel, I. Schlick, K. Schneider, M. Schumacher, M. Seidenbusch, C. Spix, B. Spors, G. Staatz, T. Vogl, J. Wagner, G. Weisser, H. Zeeb, M. Blettner |
| Abstract |
The aim of this cohort study was to assess the risk of developing cancer, specifically leukaemia, tumours of the central nervous system and lymphoma, before the age of 15 years in children previously exposed to computed tomography (CT) in Germany. Data for children with at least one CT between 1980 and 2010 were abstracted from 20 hospitals. Cancer cases occurring between 1980 and 2010 were identified by stochastic linkage with the German Childhood Cancer Registry (GCCR). For all cases and a sample of non-cases, radiology reports were reviewed to assess the underlying medical conditions at time of the CT. Cases were only included if diagnosis occurred at least 2 years after the first CT and no signs of cancer were recorded in the radiology reports. Standardised incidence ratios (SIR) using incidence rates from the general population were estimated. The cohort included information on 71,073 CT examinations in 44,584 children contributing 161,407 person-years at risk with 46 cases initially identified through linkage with the GCCR. Seven cases had to be excluded due to signs possibly suggestive of cancer at the time of first CT. Overall, more cancer cases were observed (O) than expected (E), but this was mainly driven by unexpected and possibly biased results for lymphomas. For leukaemia, the SIR (SIR = O/E) was 1.72 (95 % CI 0.89-3.01, O = 12), and for CNS tumours, the SIR was 1.35 (95 % CI 0.54-2.78, O = 7). Despite careful examination of the medical information, confounding by indication or reverse causation cannot be ruled out completely and may explain parts of the excess. Furthermore, the CT exposure may have been underestimated as only data from the participating clinics were available. This should be taken into account when interpreting risk estimates. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 2% |
| Malaysia | 1 | <1% |
| Spain | 1 | <1% |
| Luxembourg | 1 | <1% |
| Unknown | 109 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 19% |
| Student > Master | 13 | 11% |
| Student > Bachelor | 11 | 10% |
| Student > Ph. D. Student | 9 | 8% |
| Professor | 7 | 6% |
| Other | 28 | 25% |
| Unknown | 24 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 43 | 38% |
| Nursing and Health Professions | 11 | 10% |
| Biochemistry, Genetics and Molecular Biology | 7 | 6% |
| Physics and Astronomy | 5 | 4% |
| Agricultural and Biological Sciences | 3 | 3% |
| Other | 14 | 12% |
| Unknown | 31 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2015.
All research outputs
#3,301,934
of 23,815,455 outputs
Outputs from Radiation and Environmental Biophysics
#24
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Outputs of similar age
#47,148
of 356,446 outputs
Outputs of similar age from Radiation and Environmental Biophysics
#1
of 3 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 456 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 94% of its peers.
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