| Title |
Interferon lambda4 polymorphism is not associated with human papillomavirus infection outcome
|
|---|---|
| Published in |
Virus Genes, December 2017
|
| DOI | 10.1007/s11262-017-1527-y |
| Pubmed ID | |
| Authors |
Fabiana Cannella, Carolina Scagnolari, Maura Statzu, Ilaria Sciandra, Nadia Recine, Gabriella d’Ettorre, Guido Antonelli, Alessandra Pierangeli |
| Abstract |
Interferon (IFN) lambdas are important specific components of the mucosal innate immune response. The IFN lambda 4 (IFNL4) dinucleotide polymorphism (ΔG/TT) determines the IFN lambdas and related Interferon-stimulated genes activation, in HCV and other chronic infections. Our group first reported that IFN Lambda response was impaired in high-risk Human Papillomavirus (HPV) cervical infections and in precancerous lesions. Accordingly, we sought to evaluate the possible role of the IFNL4 polymorphism in determining HPV infection outcome. The ΔG/TT alleles were not differently distributed in 221 women with high- or low-risk HPV infection, with HPV infection clearance or persistence, and with abnormal cytology. |
Mendeley readers
The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 9 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 1 | 11% |
| Researcher | 1 | 11% |
| Other | 1 | 11% |
| Student > Doctoral Student | 1 | 11% |
| Unknown | 5 | 56% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 1 | 11% |
| Agricultural and Biological Sciences | 1 | 11% |
| Immunology and Microbiology | 1 | 11% |
| Medicine and Dentistry | 1 | 11% |
| Unknown | 5 | 56% |