Title |
Survival of the drowsiest: the hibernating 100S ribosome in bacterial stress management
|
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Published in |
Current Genetics, December 2017
|
DOI | 10.1007/s00294-017-0796-2 |
Pubmed ID | |
Authors |
David W. Gohara, Mee-Ngan F. Yap |
Abstract |
In response to nutrient deprivation and environmental insults, bacteria conjoin two copies of non-translating 70S ribosomes that form the translationally inactive 100S dimer. This widespread phenomenon is believed to prevent ribosome turnover and serves as a reservoir that, when conditions become favorable, allows the hibernating ribosomes to be disassembled and recycled for translation. New structural studies have revealed two distinct mechanisms for dimerizing 70S ribosomes, but the molecular basis of the disassembly process is still in its infancy. Many details regarding the sequence of dimerization-dissociation events with respect to the binding and departure of the hibernation factor and its antagonizing disassembly factor remain unclear. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 55 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 16% |
Student > Master | 9 | 16% |
Researcher | 7 | 13% |
Other | 3 | 5% |
Student > Doctoral Student | 2 | 4% |
Other | 6 | 11% |
Unknown | 19 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 22 | 40% |
Agricultural and Biological Sciences | 7 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Mathematics | 1 | 2% |
Nursing and Health Professions | 1 | 2% |
Other | 5 | 9% |
Unknown | 18 | 33% |