| Title |
Willow bark extract: The contribution of polyphenols to the overall effect
|
|---|---|
| Published in |
Wiener Medizinische Wochenschrift, July 2007
|
| DOI | 10.1007/s10354-007-0437-3 |
| Pubmed ID | |
| Authors |
Adolf Nahrstedt, Mathias Schmidt, René Jäggi, Jürgen Metz, Mohamed T. Khayyal |
| Abstract |
The efficacy of willow bark extract in the treatment of painful mobility disorders, such as back pain and arthritis, has been attributed to the content of salicin and its derivatives as pro-drugs of salicylates. However, based on clinical experience and the evidence of experimental pharmacological studies, the fraction of total salicin cannot satisfactorily explain the clinical efficacy of willow bark. In addition, salicins and their metabolites lack the acetylating potential of ASA and must therefore possess a different mechanism of action. A detailed pharmacological screening of the aqueous willow bark extract STW 33-I addressed the question of the identification of fractions contributing to the overall effect. All in vivo and in vitro models studied pointed to relevant contributions of the fraction of polyphenols and flavonoids. The single compounds or their combinations responsible for the effect remain to be elucidated. |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 1% |
| Ghana | 1 | 1% |
| Unknown | 76 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 14 | 18% |
| Student > Master | 13 | 17% |
| Researcher | 8 | 10% |
| Student > Ph. D. Student | 7 | 9% |
| Student > Doctoral Student | 5 | 6% |
| Other | 18 | 23% |
| Unknown | 13 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 21% |
| Agricultural and Biological Sciences | 15 | 19% |
| Chemistry | 10 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Other | 12 | 15% |
| Unknown | 14 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2023.
All research outputs
#7,037,679
of 24,932,492 outputs
Outputs from Wiener Medizinische Wochenschrift
#112
of 449 outputs
Outputs of similar age
#24,273
of 75,834 outputs
Outputs of similar age from Wiener Medizinische Wochenschrift
#3
of 9 outputs
Altmetric has tracked 24,932,492 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 449 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 75,834 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.