| Title |
Novel daidzein analogs enhance osteogenic activity of bone marrow-derived mesenchymal stem cells and adipose-derived stromal/stem cells through estrogen receptor dependent and independent mechanisms
|
|---|---|
| Published in |
Stem Cell Research & Therapy, August 2014
|
| DOI | 10.1186/scrt493 |
| Pubmed ID | |
| Authors |
Amy L Strong, Jason F Ohlstein, Quan Jiang, Qiang Zhang, Shilong Zheng, Stephen M Boue, Steven Elliott, Jeffrey M Gimble, Matthew E Burow, Guangdi Wang, Bruce A Bunnell |
| Abstract |
Osteoporosis is a disease characterized by low bone mineral density (BMD) and increased risk of fractures. Studies have demonstrated the use of phytoestrogens, or plant-derived estrogens, such as genistein and daidzein, to effectively increase osteogenic activity of bone marrow-derived mesenchymal stem cells (BMSCs). Herein, the effects of daidzein analogs on the osteogenic differentiation efficiency of human BMSC and adipose-derived stromal/stem cells (ASC) were explored. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 19% |
| Student > Master | 8 | 15% |
| Researcher | 6 | 12% |
| Student > Doctoral Student | 3 | 6% |
| Professor | 3 | 6% |
| Other | 7 | 13% |
| Unknown | 15 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 15% |
| Agricultural and Biological Sciences | 8 | 15% |
| Biochemistry, Genetics and Molecular Biology | 8 | 15% |
| Veterinary Science and Veterinary Medicine | 2 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 7 | 13% |
| Unknown | 17 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2015.
All research outputs
#13,419,571
of 22,778,347 outputs
Outputs from Stem Cell Research & Therapy
#961
of 2,418 outputs
Outputs of similar age
#111,906
of 236,629 outputs
Outputs of similar age from Stem Cell Research & Therapy
#13
of 19 outputs
Altmetric has tracked 22,778,347 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,418 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,629 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.