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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Basal forebrain atrophy correlates with amyloid β burden in Alzheimer's disease
|
|---|---|
| Published in |
NeuroImage: Clinical, November 2014
|
| DOI | 10.1016/j.nicl.2014.11.015 |
| Pubmed ID | |
| Authors |
Georg M Kerbler, Jürgen Fripp, Christopher C Rowe, Victor L Villemagne, Olivier Salvado, Stephen Rose, Elizabeth J Coulson, Alzheimer's Disease Neuroimaging Initiative |
| Abstract |
The brains of patients suffering from Alzheimer's disease (AD) have three classical pathological hallmarks: amyloid-beta (Aβ) plaques, tau tangles, and neurodegeneration, including that of cholinergic neurons of the basal forebrain. However the relationship between Aβ burden and basal forebrain degeneration has not been extensively studied. To investigate this association, basal forebrain volumes were determined from magnetic resonance images of controls, subjects with amnestic mild cognitive impairment (aMCI) and AD patients enrolled in the longitudinal Alzheimer's Disease Neuroimaging Initiative (ADNI) and Australian Imaging, Biomarkers and Lifestyle (AIBL) studies. In the AIBL cohort, these volumes were correlated within groups to neocortical gray matter retention of Pittsburgh compound B (PiB) from positron emission tomography images as a measure of Aβ load. The basal forebrain volumes of AD and aMCI subjects were significantly reduced compared to those of control subjects. Anterior basal forebrain volume was significantly correlated to neocortical PiB retention in AD subjects and aMCI subjects with high Aβ burden, whereas posterior basal forebrain volume was significantly correlated to neocortical PiB retention in control subjects with high Aβ burden. Therefore this study provides new evidence for a correlation between neocortical Aβ accumulation and basal forebrain degeneration. In addition, cluster analysis showed that subjects with a whole basal forebrain volume below a determined cut-off value had a 7 times higher risk of having a worse diagnosis within ~18 months. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 183 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| Netherlands | 1 | <1% |
| Australia | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Denmark | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 176 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 18% |
| Researcher | 32 | 17% |
| Student > Master | 20 | 11% |
| Student > Bachelor | 18 | 10% |
| Student > Doctoral Student | 11 | 6% |
| Other | 41 | 22% |
| Unknown | 28 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 43 | 23% |
| Medicine and Dentistry | 28 | 15% |
| Agricultural and Biological Sciences | 18 | 10% |
| Psychology | 17 | 9% |
| Computer Science | 6 | 3% |
| Other | 32 | 17% |
| Unknown | 39 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2017.
All research outputs
#1,762,553
of 25,394,764 outputs
Outputs from NeuroImage: Clinical
#173
of 2,803 outputs
Outputs of similar age
#23,355
of 369,565 outputs
Outputs of similar age from NeuroImage: Clinical
#1
of 41 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,803 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,565 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.