| Title |
Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers
|
|---|---|
| Published in |
European Journal of Nuclear Medicine and Molecular Imaging, December 2010
|
| DOI | 10.1007/s00259-010-1686-8 |
| Pubmed ID | |
| Authors |
Anders Ettrup, Martin Hansen, Martin A. Santini, James Paine, Nic Gillings, Mikael Palner, Szabolcs Lehel, Matthias M. Herth, Jacob Madsen, Jesper Kristensen, Mikael Begtrup, Gitte M. Knudsen |
| Abstract |
Positron emission tomography (PET) imaging of serotonin 2A (5-HT(2A)) receptors with agonist tracers holds promise for the selective labelling of 5-HT(2A) receptors in their high-affinity state. We have previously validated [(11)C]Cimbi-5 and found that it is a 5-HT(2A) receptor agonist PET tracer. In an attempt to further optimize the target-to-background binding ratio, we modified the chemical structure of the phenethylamine backbone and carbon-11 labelling site of [(11)C]Cimbi-5 in different ways. Here, we present the in vivo validation of nine novel 5-HT(2A) receptor agonist PET tracers in the pig brain. |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 91 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 28% |
| Student > Bachelor | 17 | 18% |
| Student > Ph. D. Student | 14 | 15% |
| Student > Master | 10 | 11% |
| Other | 6 | 6% |
| Other | 10 | 11% |
| Unknown | 10 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 26 | 28% |
| Medicine and Dentistry | 11 | 12% |
| Neuroscience | 11 | 12% |
| Agricultural and Biological Sciences | 10 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 9% |
| Other | 14 | 15% |
| Unknown | 13 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2023.
All research outputs
#5,293,800
of 24,877,869 outputs
Outputs from European Journal of Nuclear Medicine and Molecular Imaging
#661
of 3,445 outputs
Outputs of similar age
#34,162
of 193,829 outputs
Outputs of similar age from European Journal of Nuclear Medicine and Molecular Imaging
#3
of 20 outputs
Altmetric has tracked 24,877,869 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,445 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 193,829 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.