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Total brain, cortical, and white matter volumes in children previously treated with glucocorticoids

Overview of attention for article published in Pediatric Research, January 2018
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  • Above-average Attention Score compared to outputs of the same age (54th percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

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Title
Total brain, cortical, and white matter volumes in children previously treated with glucocorticoids
Published in
Pediatric Research, January 2018
DOI 10.1038/pr.2017.312
Pubmed ID
Authors

Sara K Holm, Kathrine S Madsen, Martin Vestergaard, Olaf B Paulson, Peter Uldall, Hartwig R Siebner, Alfred P Born, William F C Baaré

Abstract

Perinatal exposure to glucocorticoids and elevated endogenous glucocorticoid-levels during childhood can have detrimental effects on the developing brain. Here, we examined the impact of glucocorticoid-treatment during childhood on brain volumes. Thirty children and adolescents with rheumatic or nephrotic disease previously treated with glucocorticoids and 30 controls matched on age, sex, and parent education underwent magnetic resonance imaging (MRI) of the brain. Total cortical grey and white matter, brain, and intracranial volume, and total cortical thickness and surface area were derived from the MRI scans. Patients had significantly smaller grey and white matter and total brain volumes relative to healthy controls. Brain volume differences disappeared when accounting for intracranial volume, since patients had relatively smaller intracranial volumes. Group differences were mainly driven by the children with rheumatic disease. Total cortical thickness and cortical surface area did not significantly differ between groups. We found no significant associations between glucocorticoid-treatment variables and volumetric measures. Observed smaller total brain, cortical grey and white matter volumes in children and adolescents previously treated with glucocorticoids compared to healthy controls may reflect both developmental and degenerative processes. Prospective longitudinal studies are warranted to clarify whether findings are related to treatment or disease.Pediatric Research accepted article preview online, 18 December 2017. doi:10.1038/pr.2017.312.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Other 6 19%
Student > Ph. D. Student 5 16%
Researcher 4 13%
Student > Master 3 9%
Student > Bachelor 2 6%
Other 3 9%
Unknown 9 28%
Readers by discipline Count As %
Medicine and Dentistry 6 19%
Neuroscience 6 19%
Psychology 4 13%
Sports and Recreations 1 3%
Immunology and Microbiology 1 3%
Other 1 3%
Unknown 13 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2019.
All research outputs
#12,765,641
of 23,012,811 outputs
Outputs from Pediatric Research
#2,995
of 5,115 outputs
Outputs of similar age
#200,147
of 443,273 outputs
Outputs of similar age from Pediatric Research
#24
of 70 outputs
Altmetric has tracked 23,012,811 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,115 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 443,273 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.