| Title |
Autophagy and cell reprogramming
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, January 2015
|
| DOI | 10.1007/s00018-014-1829-3 |
| Pubmed ID | |
| Authors |
Shuo Wang, Pengyan Xia, Markus Rehm, Zusen Fan |
| Abstract |
Autophagy is an evolutionarily conserved process that degrades cytoplasmic components, thus contributing to cell survival and tissue homeostasis. Recent studies have demonstrated that autophagy maintains stem cells in relatively undifferentiated states (stemness) and also contributes to differentiation processes. Autophagy likewise plays a crucial role in somatic cell reprogramming, a finely regulated process that resets differentiated cells to a pluripotent state and that requires comprehensive alterations in transcriptional activities and epigenetic signatures. Autophagy assists in manifesting the functional consequences that arise from these alterations by modifying cellular protein expression profiles. The role of autophagy appears to be particularly relevant for early phases of cell reprogramming during the generation of induced pluripotent stems cells (iPSCs). In this review, we provide an overview of the core molecular machinery that constitutes the autophagic degradation system, describe the roles of autophagy in maintenance, self-renewal, and differentiation of stem cells, and discuss the autophagic process and its regulation during cell reprogramming. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 50% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 3 | 3% |
| Iran, Islamic Republic of | 1 | 1% |
| Korea, Republic of | 1 | 1% |
| Japan | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 80 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 23% |
| Student > Master | 14 | 16% |
| Researcher | 12 | 14% |
| Student > Bachelor | 9 | 10% |
| Professor > Associate Professor | 6 | 7% |
| Other | 11 | 13% |
| Unknown | 15 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 33% |
| Biochemistry, Genetics and Molecular Biology | 28 | 32% |
| Medicine and Dentistry | 5 | 6% |
| Immunology and Microbiology | 2 | 2% |
| Neuroscience | 2 | 2% |
| Other | 5 | 6% |
| Unknown | 16 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2015.
All research outputs
#3,892,450
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#702
of 4,151 outputs
Outputs of similar age
#53,739
of 356,162 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#7
of 57 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 356,162 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.