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Mendeley readers
Attention Score in Context
| Title |
Understanding the complexity and malleability of T‐cell recognition
|
|---|---|
| Published in |
Immunology & Cell Biology, January 2015
|
| DOI | 10.1038/icb.2014.112 |
| Pubmed ID | |
| Authors |
John J Miles, James McCluskey, Jamie Rossjohn, Stephanie Gras |
| Abstract |
T cells are the master regulators of immune system function, continually walking the biological tightrope between adequate host defence and accidental host pathology. Tolerance is maintained or broken through an intricate structural interplay between the T-cell receptor (TCR) and major histocompatibility complex (MHC) molecule cradling peptide antigens (p). Recent advances in structural biology have shown that the TCR/pMHC interface is surprising precise and extraordinarily malleable. We have seen that seemingly minor changes in the TCR/pMHC interface can abrogate function, as well as substantial conformational changes before and after TCR docking. Our understanding of T-cell biology has also been altered with the knowledge that MHC molecules can bind not only peptides, but also an array of natural and synthetic compounds. Here, we review some examples of the precision and flexibility intrinsic to the TCR/p/MHCI axis.Immunology and Cell Biology advance online publication, 13 January 2015; doi:10.1038/icb.2014.112. |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| United States | 1 | 2% |
| Russia | 1 | 2% |
| Unknown | 60 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 30% |
| Student > Bachelor | 8 | 13% |
| Researcher | 7 | 11% |
| Student > Master | 6 | 10% |
| Student > Doctoral Student | 5 | 8% |
| Other | 11 | 17% |
| Unknown | 7 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 29% |
| Immunology and Microbiology | 11 | 17% |
| Medicine and Dentistry | 10 | 16% |
| Biochemistry, Genetics and Molecular Biology | 8 | 13% |
| Engineering | 2 | 3% |
| Other | 6 | 10% |
| Unknown | 8 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2024.
All research outputs
#3,415,054
of 25,373,627 outputs
Outputs from Immunology & Cell Biology
#268
of 1,848 outputs
Outputs of similar age
#45,895
of 360,419 outputs
Outputs of similar age from Immunology & Cell Biology
#19
of 35 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,848 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,419 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.