| Title |
Association of Elevated NT-proBNP With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis (MESA)
|
|---|---|
| Published in |
JACC, December 2017
|
| DOI | 10.1016/j.jacc.2017.10.044 |
| Pubmed ID | |
| Authors |
Chia-Ying Liu, Susan R. Heckbert, Shenghan Lai, Bharath Ambale-Venkatesh, Mohammad R. Ostovaneh, Robyn L. McClelland, João A.C. Lima, David A. Bluemke |
| Abstract |
Serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) is considered a marker that is expressed in response to myocardial strain and possibly fibrosis. However, the relationship to myocardial fibrosis in a community-based population is unknown. The authors evaluated the relationship between cardiac magnetic resonance (CMR) measures of fibrosis and NT-proBNP levels in the MESA (Multi-Ethnic Study of Atherosclerosis) study. A total of 1,334 participants (52% white, 23% black, 11% Chinese, 14% Hispanic, and 52% men with a mean age of 67.6 years) at 6 sites had both serum NT-proBNP measurements and CMR with T1 mapping of indices of fibrosis at 1.5 T. Univariate and multivariable regression analyses adjusting for demographics, cardiovascular risk factors, and left ventricular (LV) mass were performed to examine the association of log NT-proBNP with CMR T1 mapping indices. In the fully adjusted model, each 1-SD increment (0.44 pg/ml) of log NT-proBNP was associated with a 0.62% increment in extracellular volume fraction (p < 0.001), 0.011 increment in partition coefficient (p < 0.001), and 4.7-ms increment in native T1 (p = 0.001). Results remained unchanged after excluding individuals with clinical cardiovascular disease or late gadolinium enhancement (n = 167), and after replacing LV mass by LV end-diastolic volume in the regression models. Elevated NT-proBNP is related to subclinical fibrosis in a community-based setting. (Multi-Ethnic Study of Atherosclerosis [MESA]; NCT00005487). |
X Demographics
The data shown below were collected from the profiles of 33 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 27% |
| Spain | 5 | 15% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| United Kingdom | 1 | 3% |
| Mexico | 1 | 3% |
| Croatia | 1 | 3% |
| Argentina | 1 | 3% |
| Switzerland | 1 | 3% |
| Canada | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 10 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 61% |
| Practitioners (doctors, other healthcare professionals) | 6 | 18% |
| Science communicators (journalists, bloggers, editors) | 4 | 12% |
| Scientists | 3 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 12% |
| Researcher | 6 | 12% |
| Student > Doctoral Student | 5 | 10% |
| Other | 5 | 10% |
| Student > Postgraduate | 5 | 10% |
| Other | 12 | 23% |
| Unknown | 13 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 48% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Psychology | 2 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Nursing and Health Professions | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 19 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2019.
All research outputs
#1,501,042
of 25,658,541 outputs
Outputs from JACC
#3,460
of 16,836 outputs
Outputs of similar age
#33,006
of 446,791 outputs
Outputs of similar age from JACC
#87
of 179 outputs
Altmetric has tracked 25,658,541 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 16,836 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.0. This one has done well, scoring higher than 79% of its peers.
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We're also able to compare this research output to 179 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.