Title |
High-speed atomic force microscopy and its future prospects
|
---|---|
Published in |
Biophysical Reviews, December 2017
|
DOI | 10.1007/s12551-017-0356-5 |
Pubmed ID | |
Authors |
Toshio Ando |
Abstract |
Various techniques have been developed and used to investigate how proteins produce complex biological architectures and phenomena. Among these techniques, high-speed atomic force microscopy (HS-AFM) holds a unique position. It is only HS-AFM that allows the simultaneous assessment of structure and dynamics of single protein molecules in action. This new microscopy tool has been successfully applied to a variety of proteins, from motor proteins to membrane proteins, antibodies, enzymes, and even to intrinsically disordered proteins. And yet there still remain many biomolecular phenomena that cannot be addressed by HS-AFM in its current form. Here, I present a brief history of HS-AFM development, describe the current state of HS-AFM, and then discuss which new biological scanning probe microscopy techniques will be coming up next. |
X Demographics
Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 217 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 36 | 17% |
Student > Master | 31 | 14% |
Researcher | 27 | 12% |
Student > Bachelor | 25 | 12% |
Student > Doctoral Student | 12 | 6% |
Other | 24 | 11% |
Unknown | 62 | 29% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 38 | 18% |
Engineering | 22 | 10% |
Physics and Astronomy | 21 | 10% |
Chemistry | 18 | 8% |
Materials Science | 16 | 7% |
Other | 28 | 13% |
Unknown | 74 | 34% |