| Title |
Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures—results from the ICUROS
|
|---|---|
| Published in |
Osteoporosis International, December 2017
|
| DOI | 10.1007/s00198-017-4317-4 |
| Pubmed ID | |
| Authors |
A. Svedbom, F. Borgstöm, E. Hernlund, O. Ström, V. Alekna, M. L. Bianchi, P. Clark, M. D. Curiel, H. P. Dimai, M. Jürisson, R. Kallikorm, M. Lember, O. Lesnyak, E. McCloskey, K. M. Sanders, S. Silverman, A. Solodovnikov, M. Tamulaitiene, T. Thomas, N. Toroptsova, A. Uusküla, A. N. A. Tosteson, B. Jönsson, J. A. Kanis |
| Abstract |
This study used data from the International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) to estimate the quality of life (QoL) impact of fracture. Hip, vertebral, and distal forearm fractures incur substantial QoL losses. Hip and vertebral fracture results in markedly impaired QoL for at least 18 months. The International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) is a multinational observational study that aims to describe costs and quality of life (QoL) consequences of osteoporotic fractures. To date, 11 countries have participated in the study: Australia, Austria, Estonia, France, Italy, Lithuania, Mexico, Russia, Spain, the UK, and the USA. The objective of this paper is to describe the QoL impact of hip, vertebral, and distal forearm fracture. Data were collected at four time-points for five QoL point estimates: within 2 weeks after fracture (including pre-fracture recall) and at 4, 12, and 18 months after fracture. Quality of life was measured as health state utility values (HSUVs) derived from the EQ-5D-3L. Complete case analysis was conducted as the base case with available case and multiple imputation performed as sensitivity analyses. Multivariate analysis was performed to explore predictors of QoL impact of fracture. Among 5456 patients enrolled using convenience sampling, 3021 patients were eligible for the base case analysis (1415 hip, 1047 distal forearm, and 559 vertebral fractures). The mean (SD) difference between HSUV before and after fracture for hip, vertebral, and distal forearm fracture was estimated at 0.89 (0.40), 0.67 (0.45), and 0.48 (0.34), respectively (p < 0.001 for all fracture types). Eighteen months after fracture, mean HSUVs were lower than before the fracture in patients with hip fracture (0.66 vs. 0.77 p < 0.001) and vertebral fracture (0.70 vs. 0.83 p < 0.001). Hospitalization and higher recalled pre-fracture QoL were associated with increased QoL impact for all fracture types. Hip, vertebral, and distal forearm fractures incur substantial loss in QoL and for patients with hip or vertebral fracture, QoL is markedly impaired for at least 18 months. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 14% |
| Spain | 1 | 14% |
| Switzerland | 1 | 14% |
| France | 1 | 14% |
| Australia | 1 | 14% |
| Netherlands | 1 | 14% |
| Unknown | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Scientists | 2 | 29% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 79 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 16% |
| Researcher | 11 | 14% |
| Student > Ph. D. Student | 9 | 11% |
| Student > Bachelor | 5 | 6% |
| Student > Doctoral Student | 3 | 4% |
| Other | 12 | 15% |
| Unknown | 26 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 25% |
| Nursing and Health Professions | 9 | 11% |
| Economics, Econometrics and Finance | 4 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Other | 11 | 14% |
| Unknown | 29 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2023.
All research outputs
#4,256,276
of 23,986,470 outputs
Outputs from Osteoporosis International
#714
of 3,769 outputs
Outputs of similar age
#87,833
of 446,659 outputs
Outputs of similar age from Osteoporosis International
#10
of 54 outputs
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