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Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium

Overview of attention for article published in Cancer Science, January 2018
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Title
Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium
Published in
Cancer Science, January 2018
DOI 10.1111/cas.13470
Pubmed ID
Authors

Tomotaka Ugai, Linda E. Kelemen, Mika Mizuno, Jue‐Sheng Ong, Penelope M. Webb, Georgia Chenevix‐Trench, on behalf of the Australian Ovarian Cancer Study Group, Kristine G. Wicklund, Jennifer Anne Doherty, Mary Anne Rossing, Pamela J. Thompson, Lynne R. Wilkens, Michael E. Carney, Marc T. Goodman, Joellen M. Schildkraut, Andrew Berchuck, Daniel W. Cramer, Kathryn L. Terry, Hui Cai, Xiao‐Ou Shu, Yu‐Tang Gao, Yong‐Bing Xiang, David Van Den Berg, Malcom C Pike, Anna H. Wu, Celeste Leigh Pearce, Keitaro Matsuo, on behalf of the Ovarian Cancer Association Consortium

Abstract

The ALDH2 polymorphism rs671 (Glu504Lys) causes ALDH2 inactivation and adverse acetaldehyde exposure among Asians, but little is known of the association between alcohol consumption and rs671 and ovarian cancer (OvCa) in Asians. We conducted a pooled analysis of Asian ancestry participants in the Ovarian Cancer Association Consortium. We included seven case-control studies and one cohort study comprising 460 invasive OvCa cases, 37 borderline mucinous OvCa and 1,274 controls of Asian descent with information on recent alcohol consumption. The pooled odds ratios (OR) with 95% confidence intervals (CI) for OvCa risk associated with alcohol consumption, rs671 and their interaction were estimated using logistic regression models adjusted for potential confounders. No significant association was observed for daily alcohol intake with invasive OvCa (OR comparing any consumption to none =0.83; 95% CI=0.58-1.18) or with individual histotypes. A significant decreased risk was seen for carriers of one or both Lys alleles of rs671 for invasive mucinous OvCa (OR=0.44; 95% CI=0.20-0.97) and for invasive and borderline mucinous tumors combined (OR=0.48; 95% CI=0.26-0.89). No significant interaction was observed between alcohol consumption and rs671 genotypes. In conclusion, self-reported alcohol consumption at the quantities estimated was not associated with OvCa risk among Asians. Because the rs671 Lys allele causes ALDH2 inactivation leading to increased acetaldehyde exposure, the observed inverse genetic association with mucinous ovarian cancer is inferred to mean that alcohol intake may be a risk factor for this histotype. This association will require replication in a larger sample. This article is protected by copyright. All rights reserved.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 18%
Student > Bachelor 4 14%
Researcher 4 14%
Student > Ph. D. Student 1 4%
Other 1 4%
Other 0 0%
Unknown 13 46%
Readers by discipline Count As %
Medicine and Dentistry 7 25%
Immunology and Microbiology 2 7%
Nursing and Health Professions 1 4%
Agricultural and Biological Sciences 1 4%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 3 11%
Unknown 13 46%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 December 2018.
All research outputs
#18,579,736
of 23,012,811 outputs
Outputs from Cancer Science
#1,860
of 2,683 outputs
Outputs of similar age
#330,551
of 441,372 outputs
Outputs of similar age from Cancer Science
#19
of 30 outputs
Altmetric has tracked 23,012,811 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,683 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 441,372 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.