| Title |
Adolescent cocaine exposure induces prolonged synaptic modifications in medial prefrontal cortex of adult rats
|
|---|---|
| Published in |
Brain Structure and Function, December 2017
|
| DOI | 10.1007/s00429-017-1590-0 |
| Pubmed ID | |
| Authors |
Wei Zhu, Xuhui Ge, Peng Gao, Min Li, Yun Guan, Xiaowei Guan |
| Abstract |
Substance used during adolescent period increases the risk of psychiatric disorders in later life, but the underlying neural mechanisms remain unclear. We hypothesize that synaptic remodeling and changes of homeostasis in the medial prefrontal cortex (mPFC) following adolescent cocaine exposure may last for a long time, and these modifications may contribute to behavioral deficiencies in adulthood. To address this hypothesis, rats were exposed to cocaine hydrochloride from postnatal day 28 (P28) to P42. When reared to adulthood, rats were subjected to behavioral tests. On P75 and P76, cocaine-experienced rats exhibited increased locomotive and anxiety-like behaviors, as well as impaired non-selective attention. In the cocaine-experienced rats, both levels of synapse-related proteins (synapsin I and PSD-95) and density of synapse and dendrite spine in mPFC were significantly decreased when compared to controls. Unexpected, the expression of molecules related to oxidative stress, inflammation and apoptosis showed no significant changes in mPFC following adolescent cocaine exposure. These findings suggested that adolescent exposure to cocaine induce long-term modification on synapses in mPFC, which might contribute to long-term behavioral outcomes in adulthood. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 15% |
| Student > Doctoral Student | 4 | 15% |
| Researcher | 3 | 11% |
| Professor > Associate Professor | 2 | 7% |
| Lecturer | 1 | 4% |
| Other | 4 | 15% |
| Unknown | 9 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 6 | 22% |
| Agricultural and Biological Sciences | 2 | 7% |
| Psychology | 2 | 7% |
| Medicine and Dentistry | 2 | 7% |
| Nursing and Health Professions | 1 | 4% |
| Other | 4 | 15% |
| Unknown | 10 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2017.
All research outputs
#21,697,638
of 24,217,893 outputs
Outputs from Brain Structure and Function
#1,524
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Outputs of similar age
#383,097
of 447,398 outputs
Outputs of similar age from Brain Structure and Function
#44
of 58 outputs
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