Title |
Acute Cerebellar Ataxia Induced by Nivolumab
|
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Published in |
Internal Medicine, December 2017
|
DOI | 10.2169/internalmedicine.8895-17 |
Pubmed ID | |
Authors |
Reina Kawamura, Eiichiro Nagata, Masako Mukai, Yoichi Ohnuki, Tomohiko Matsuzaki, Kana Ohiwa, Tomoki Nakagawa, Mitsutomo Kohno, Ryota Masuda, Masayuki Iwazaki, Shunya Takizawa |
Abstract |
A 54-year-old woman with adenocarcinoma of the lung and lymph node metastasis experienced nystagmus and cerebellar ataxia 2 weeks after initiating nivolumab therapy. An evaluation for several autoimmune-related antibodies and paraneoplastic syndrome yielded negative results. We eventually diagnosed the patient with nivolumab-induced acute cerebellar ataxia, after excluding other potential conditions. Her ataxic gait and nystagmus resolved shortly after intravenous steroid pulse therapy followed by the administration of decreasing doses of oral steroids. Nivolumab, an immune checkpoint inhibitor, is known to induce various neurological adverse events. However, this is the first report of acute cerebellar ataxia associated with nivolumab treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 25% |
Argentina | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Scientists | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 42 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 19% |
Student > Bachelor | 6 | 14% |
Student > Doctoral Student | 5 | 12% |
Researcher | 4 | 10% |
Student > Postgraduate | 4 | 10% |
Other | 8 | 19% |
Unknown | 7 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 38% |
Nursing and Health Professions | 5 | 12% |
Agricultural and Biological Sciences | 3 | 7% |
Neuroscience | 3 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Other | 4 | 10% |
Unknown | 9 | 21% |