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X Demographics
Mendeley readers
Attention Score in Context
| Title |
TRP channel–associated factors are a novel protein family that regulates TRPM8 trafficking and activity
|
|---|---|
| Published in |
Journal of Cell Biology, January 2015
|
| DOI | 10.1083/jcb.201402076 |
| Pubmed ID | |
| Authors |
Dimitra Gkika, Loic Lemonnier, George Shapovalov, Dmitri Gordienko, Céline Poux, Michela Bernardini, Alexandre Bokhobza, Gabriel Bidaux, Cindy Degerny, Kathye Verreman, Basma Guarmit, Mohamed Benahmed, Yvan de Launoit, Rene J.M. Bindels, Alessandra Fiorio Pla, Natalia Prevarskaya |
| Abstract |
TRPM8 is a cold sensor that is highly expressed in the prostate as well as in other non-temperature-sensing organs, and is regulated by downstream receptor-activated signaling pathways. However, little is known about the intracellular proteins necessary for channel function. Here, we identify two previously unknown proteins, which we have named "TRP channel-associated factors" (TCAFs), as new TRPM8 partner proteins, and we demonstrate that they are necessary for channel function. TCAF1 and TCAF2 both bind to the TRPM8 channel and promote its trafficking to the cell surface. However, they exert opposing effects on TRPM8 gating properties. Functional interaction of TCAF1/TRPM8 also leads to a reduction in both the speed and directionality of migration of prostate cancer cells, which is consistent with an observed loss of expression of TCAF1 in metastatic human specimens, whereas TCAF2 promotes migration. The identification of TCAFs introduces a novel mechanism for modulation of TRPM8 channel activity. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Italy | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 122 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 19% |
| Student > Ph. D. Student | 19 | 15% |
| Student > Master | 13 | 10% |
| Student > Bachelor | 12 | 9% |
| Professor > Associate Professor | 11 | 9% |
| Other | 19 | 15% |
| Unknown | 30 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 39 | 30% |
| Agricultural and Biological Sciences | 29 | 23% |
| Chemistry | 6 | 5% |
| Neuroscience | 5 | 4% |
| Medicine and Dentistry | 4 | 3% |
| Other | 13 | 10% |
| Unknown | 32 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2015.
All research outputs
#19,944,091
of 25,373,627 outputs
Outputs from Journal of Cell Biology
#11,427
of 11,939 outputs
Outputs of similar age
#251,961
of 358,844 outputs
Outputs of similar age from Journal of Cell Biology
#68
of 82 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,939 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 358,844 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.