| Title |
Predictors and outcomes of Mycobacterium tuberculosis bacteremia among patients with HIV and tuberculosis co-infection enrolled in the ACTG A5221 STRIDE study
|
|---|---|
| Published in |
BMC Infectious Diseases, January 2015
|
| DOI | 10.1186/s12879-014-0735-5 |
| Pubmed ID | |
| Authors |
John A Crump, Xingye Wu, Michelle A Kendall, Prudence D Ive, Johnstone J Kumwenda, Beatriz Grinsztejn, Ute Jentsch, Susan Swindells |
| Abstract |
BackgroundTo evaluate predictors and outcomes of Mycobacterium tuberculosis bacteremia among participants undergoing baseline mycobacterial blood culture in the ACTG A5221 STRIDE study, a randomized clinical trial comparing earlier with later ART among HIV-infected patients suspected of having tuberculosis with CD4-positive T-lymphocyte counts (CD4 counts) <250 cells/mm3. We conducted a secondary analysis comparing participants with respect to presence or absence of M. tuberculosis bacteremia.MethodsParticipants with a baseline mycobacterial blood culture were compared with respect to the presence or absence of M. tuberculosis bacteremia. Baseline predictors of M. tuberculosis bacteremia were identified and participant outcomes were compared by mycobacteremia status.ResultsOf 90 participants with baseline mycobacterial blood cultures, 29 (32.2%) were female, the median (IQR) age was 37 (31¿45) years, CD4 count was 81 (33¿131) cells/mm3, HIV-1 RNA level was 5.39 (4.96¿5.83) log10 copies/mL, and 18 (20.0%) were positive for M. tuberculosis. In multivariable analysis, lower CD4 count (OR 0.85 per 10-cell increase, p¿=¿0.012), hemoglobin ¿8.5 g/dL (OR 5.8, p¿=¿0.049), and confirmed tuberculosis (OR 17.4, p¿=¿0.001) were associated with M. tuberculosis bacteremia. There were no significant differences in survival and AIDS-free survival, occurrence of tuberculosis IRIS, or treatment interruption or discontinuation by M. tuberculosis bacteremia status. IRIS did not differ significantly between groups despite trends toward more virologic suppression and greater CD4 count increases at week 48 in the bacteremic group.ConclusionsAmong HIV-infected tuberculosis suspects, lower CD4 count, hemoglobin ¿8.5 g/dL, and the presence of microbiologically confirmed pulmonary tuberculosis were associated with increased adjusted odds of mycobacteremia. No evidence of an association between M. tuberculosis bacteremia and the increased risk of IRIS was detected.Trial registrationClinicalTrials.gov: NCT00108862. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| United Kingdom | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ethiopia | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 119 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 23 | 19% |
| Researcher | 19 | 16% |
| Student > Ph. D. Student | 16 | 13% |
| Student > Bachelor | 10 | 8% |
| Student > Postgraduate | 8 | 7% |
| Other | 20 | 17% |
| Unknown | 25 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 39 | 32% |
| Nursing and Health Professions | 13 | 11% |
| Immunology and Microbiology | 7 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 6% |
| Social Sciences | 5 | 4% |
| Other | 20 | 17% |
| Unknown | 30 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2020.
All research outputs
#13,187,118
of 22,778,347 outputs
Outputs from BMC Infectious Diseases
#3,160
of 7,670 outputs
Outputs of similar age
#169,158
of 353,085 outputs
Outputs of similar age from BMC Infectious Diseases
#64
of 188 outputs
Altmetric has tracked 22,778,347 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,670 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,085 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 188 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.