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Mendeley readers
Attention Score in Context
| Title |
Solution Structure, Aggregation Behavior, and Flexibility of Human Relaxin‑2
|
|---|---|
| Published in |
ACS Chemical Biology, January 2015
|
| DOI | 10.1021/cb500918v |
| Pubmed ID | |
| Authors |
Linda M. Haugaard-Kedström, Mohammed Akhter Hossain, Norelle L. Daly, Ross A. D. Bathgate, Ernst Rinderknecht, John D. Wade, David J. Craik, K. Johan Rosengren |
| Abstract |
Relaxin is a member of the relaxin/insulin peptide hormone superfamily and is characterized by a two-chain structure constrained by three disulfide bonds. Relaxin is a pleiotropic hormone and involved in a number of physiological and pathogenic processes, including collagen and cardiovascular regulation and tissue remodelling during pregnancy and cancer. Crystallographic and ultracentrifugation experiments have revealed that the human form of relaxin, H2 relaxin, self-associates into dimers, but the significance of this is poorly understood. Here, we present the NMR structure of a monomeric, amidated form of H2 relaxin and compare its features and behavior in solution to those of native H2 relaxin. The overall structure of H2 relaxin is retained in the monomeric form. H2 relaxin amide is fully active at the relaxin receptor RXFP1 and thus dimerization is not required for biological activity. Analysis of NMR chemical shifts and relaxation parameters identified internal motion in H2 relaxin at the pico-nanosecond and milli-microsecond time scales, which is commonly seen in other relaxin and insulin peptides and might be related to function. |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Australia | 1 | 3% |
| Unknown | 33 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 26% |
| Student > Bachelor | 5 | 14% |
| Researcher | 5 | 14% |
| Student > Postgraduate | 3 | 9% |
| Student > Master | 2 | 6% |
| Other | 5 | 14% |
| Unknown | 6 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 23% |
| Chemistry | 7 | 20% |
| Biochemistry, Genetics and Molecular Biology | 4 | 11% |
| Immunology and Microbiology | 3 | 9% |
| Medicine and Dentistry | 3 | 9% |
| Other | 2 | 6% |
| Unknown | 8 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2023.
All research outputs
#7,756,853
of 23,578,918 outputs
Outputs from ACS Chemical Biology
#1,815
of 3,331 outputs
Outputs of similar age
#116,896
of 383,152 outputs
Outputs of similar age from ACS Chemical Biology
#49
of 90 outputs
Altmetric has tracked 23,578,918 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,331 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 383,152 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.