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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma
|
|---|---|
| Published in |
Nature Communications, January 2015
|
| DOI | 10.1038/ncomms6965 |
| Pubmed ID | |
| Authors |
Catherine Igartua, Rachel A. Myers, Rasika A. Mathias, Maria Pino-Yanes, Celeste Eng, Penelope E. Graves, Albert M. Levin, Blanca E. Del-Rio-Navarro, Daniel J. Jackson, Oren E. Livne, Nicholas Rafaels, Christopher K. Edlund, James J. Yang, Scott Huntsman, Muhammad T. Salam, Isabelle Romieu, Raphael Mourad, James E. Gern, Robert F. Lemanske, Annah Wyss, Jane A. Hoppin, Kathleen C. Barnes, Esteban G. Burchard, W. James Gauderman, Fernando D. Martinez, Benjamin A. Raby, Scott T. Weiss, L. Keoki Williams, Stephanie J. London, Frank D. Gilliland, Dan L. Nicolae, Carole Ober |
| Abstract |
Common variants at many loci have been robustly associated with asthma but explain little of the overall genetic risk. Here we investigate the role of rare (<1%) and low-frequency (1-5%) variants using the Illumina HumanExome BeadChip array in 4,794 asthma cases, 4,707 non-asthmatic controls and 590 case-parent trios representing European Americans, African Americans/African Caribbeans and Latinos. Our study reveals one low-frequency missense mutation in the GRASP gene that is associated with asthma in the Latino sample (P=4.31 × 10(-6); OR=1.25; MAF=1.21%) and two genes harbouring functional variants that are associated with asthma in a gene-based analysis: GSDMB at the 17q12-21 asthma locus in the Latino and combined samples (P=7.81 × 10(-8) and 4.09 × 10(-8), respectively) and MTHFR in the African ancestry sample (P=1.72 × 10(-6)). Our results suggest that associations with rare and low-frequency variants are ethnic specific and not likely to explain a significant proportion of the 'missing heritability' of asthma. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 31% |
| Germany | 1 | 8% |
| Israel | 1 | 8% |
| Puerto Rico | 1 | 8% |
| Spain | 1 | 8% |
| Unknown | 5 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 62% |
| Scientists | 3 | 23% |
| Practitioners (doctors, other healthcare professionals) | 1 | 8% |
| Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 4% |
| Unknown | 71 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 20% |
| Student > Ph. D. Student | 13 | 18% |
| Professor | 7 | 9% |
| Student > Bachelor | 6 | 8% |
| Professor > Associate Professor | 6 | 8% |
| Other | 16 | 22% |
| Unknown | 11 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 23 | 31% |
| Medicine and Dentistry | 15 | 20% |
| Agricultural and Biological Sciences | 12 | 16% |
| Nursing and Health Professions | 2 | 3% |
| Computer Science | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 15 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 62. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2019.
All research outputs
#645,616
of 24,417,958 outputs
Outputs from Nature Communications
#11,133
of 52,320 outputs
Outputs of similar age
#8,689
of 361,542 outputs
Outputs of similar age from Nature Communications
#107
of 672 outputs
Altmetric has tracked 24,417,958 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 52,320 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.2. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,542 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 672 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.