| Title |
Advances in small molecule inhibitors of androgen receptor for the treatment of advanced prostate cancer
|
|---|---|
| Published in |
World Journal of Urology, August 2011
|
| DOI | 10.1007/s00345-011-0745-5 |
| Pubmed ID | |
| Authors |
Marianne D. Sadar |
| Abstract |
Current treatments for localized prostate cancer include brachytherapy, external beam radiation, surgery, and active surveillance. Unfortunately, 20-40% of prostate cancer patients will experience recurrence and require hormonal therapies. These therapies involve androgen ablation by chemical or surgical castration and application of antiandrogens. Hormonal therapy is initially effective, but will inevitably fail and the disease will progress to lethal castration-resistant prostate cancer (CRPC) from which patients succumb within 2 years. CRPC is considered to be dependent on transcriptionally active androgen receptors (AR). This article reviews recent advances in the discovery and development of small molecule inhibitors of AR. |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 3% |
| Unknown | 39 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 23% |
| Student > Bachelor | 7 | 18% |
| Other | 5 | 13% |
| Researcher | 5 | 13% |
| Professor > Associate Professor | 3 | 8% |
| Other | 7 | 18% |
| Unknown | 4 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 10 | 25% |
| Medicine and Dentistry | 8 | 20% |
| Agricultural and Biological Sciences | 6 | 15% |
| Biochemistry, Genetics and Molecular Biology | 4 | 10% |
| Computer Science | 1 | 3% |
| Other | 5 | 13% |
| Unknown | 6 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2023.
All research outputs
#3,399,989
of 23,477,147 outputs
Outputs from World Journal of Urology
#303
of 2,155 outputs
Outputs of similar age
#17,127
of 122,307 outputs
Outputs of similar age from World Journal of Urology
#1
of 13 outputs
Altmetric has tracked 23,477,147 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,155 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,307 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.