| Title |
Wechsel des LHRH-Analogons beim progredienten kastrationsresistenten Prostatakarzinom
|
|---|---|
| Published in |
Die Urologie, June 2012
|
| DOI | 10.1007/s00120-012-2948-9 |
| Pubmed ID | |
| Authors |
A. Heidenreich, D. Porres, R. Epplen, T. van Erps, D. Pfister |
| Abstract |
Medicinal or surgical castration remains the treatment of choice in metastatic, hormone-naive prostate cancer; however, 2-12% of patients never reach the target serum levels for medicinal castration. We analyzed the therapeutic efficacy of triptorelin pamoate (TP) as salvage treatment due to its higher potency than endogenous luteinizing hormone-releasing hormone (LHRH). The amino acid sequence of TP is identical to that of endogenous LHRH except for position 6 where L-glycine is replaced by D-tryptophane rendering the synthetic moiety less susceptible to cleavage by proteolytic enzymes. |
Mendeley readers
The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 1 | 20% |
| Unknown | 4 | 80% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 1 | 20% |
| Unknown | 4 | 80% |