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Diagnostic performance of expression of PCA3, Hepsin and miR biomarkers inejaculate in combination with serum PSA for the detection of prostate cancer

Overview of attention for article published in The Prostate, January 2015
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Title
Diagnostic performance of expression of PCA3, Hepsin and miR biomarkers inejaculate in combination with serum PSA for the detection of prostate cancer
Published in
The Prostate, January 2015
DOI 10.1002/pros.22942
Pubmed ID
Authors

Matthew J. Roberts, Clement W. K. Chow, Horst Joachim Schirra, Renee Richards, Marion Buck, Luke A. Selth, Suhail A. R. Doi, Hema Samaratunga, Joanna Perry‐Keene, Diane Payton, John Yaxley, Martin F. Lavin, Robert A. Gardiner

Abstract

Here, we report on the evaluation of the diagnostic performance of ejaculate-derived PCA3, Hepsin, and miRNAs to complement serum PSA to detect prostate cancer. cDNA was prepared from 152 candidate specimens following RNA isolation and amplification for PSA, PCA3 and Hepsin qPCR, with 66 having adequate RNA for all three assays. Small RNA sequencing and examination of PCa-associated miRNAs miR-200b, miR-200c, miR-375 and miR-125b was performed on 20 specimens. We compared findings from prostate biopsies using D'Amico and PRIAS classifications and in relation to whole gland histopathology following radical prostatectomy. Multivariate logistic regression modeling and clinical risk (incorporating standard clinicopathological variables) were performed for all ejaculate-based markers.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 60 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 14 23%
Student > Master 9 15%
Student > Ph. D. Student 8 13%
Researcher 5 8%
Student > Doctoral Student 3 5%
Other 8 13%
Unknown 13 22%
Readers by discipline Count As %
Medicine and Dentistry 16 27%
Biochemistry, Genetics and Molecular Biology 10 17%
Agricultural and Biological Sciences 10 17%
Engineering 2 3%
Chemistry 2 3%
Other 4 7%
Unknown 16 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2015.
All research outputs
#22,024,252
of 24,571,708 outputs
Outputs from The Prostate
#2,401
of 2,634 outputs
Outputs of similar age
#308,755
of 362,232 outputs
Outputs of similar age from The Prostate
#28
of 35 outputs
Altmetric has tracked 24,571,708 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,634 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.