Title |
Gastrointestinal Stromal Tumors: The GIST of Precision Medicine
|
---|---|
Published in |
Trends in Cancer, December 2017
|
DOI | 10.1016/j.trecan.2017.11.006 |
Pubmed ID | |
Authors |
Lin Mei, Steven C. Smith, Anthony C. Faber, Jonathan Trent, Steven R. Grossman, Constantine A. Stratakis, Sosipatros A. Boikos |
Abstract |
The discovery of activated KIT mutations in gastrointestinal (GI) stromal tumors (GISTs) in 1998 triggered a sea change in our understanding of these tumors and has ushered in a new paradigm for the use of molecular genetic diagnostics to guide targeted therapies. KIT and PDGFRA mutations account for 85-90% of GISTs; subsequent genetic studies have led to the identification of mutation/epimutation of additional genes, including the succinate dehydrogenase (SDH) subunit A, B, C, and D genes. This review focuses on integrating findings from clinicopathologic, genetic, and epigenetic studies, which classify GISTs into two distinct clusters: an SDH-competent group and an SDH-deficient group. This development is important since it revolutionizes our current management of affected patients and their relatives, fundamentally, based on the GIST genotype. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 10 | 38% |
Spain | 2 | 8% |
India | 1 | 4% |
Canada | 1 | 4% |
Germany | 1 | 4% |
Unknown | 11 | 42% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 18 | 69% |
Scientists | 5 | 19% |
Science communicators (journalists, bloggers, editors) | 2 | 8% |
Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 60 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 8 | 13% |
Researcher | 6 | 10% |
Student > Master | 6 | 10% |
Student > Doctoral Student | 5 | 8% |
Student > Postgraduate | 5 | 8% |
Other | 12 | 20% |
Unknown | 18 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 28% |
Biochemistry, Genetics and Molecular Biology | 7 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
Agricultural and Biological Sciences | 3 | 5% |
Immunology and Microbiology | 3 | 5% |
Other | 7 | 12% |
Unknown | 18 | 30% |