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Mitoimmunity—when mitochondria dictates macrophage function

Overview of attention for article published in Cell Biology International, January 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

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3 X users
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1 Facebook page

Citations

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40 Mendeley
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Title
Mitoimmunity—when mitochondria dictates macrophage function
Published in
Cell Biology International, January 2018
DOI 10.1002/cbin.10921
Pubmed ID
Authors

Felipe Corrêa‐da‐Silva, Jéssica A. S. Pereira, Cristhiane F. de Aguiar, Pedro M. M. de Moraes‐Vieira

Abstract

In the past decade, several reports have appointed the importance of mitochondria in the immune response. Our understanding of mitochondria evolved from a simple supplier of energy into a platform necessary for immunorregulation. Proinflammatory responses are associated with enhanced glycolytic activity and breakdown of the TCA cycle. Mitochondrial reactive species of oxygen (mROS) are key regulators of classically activated macrophages, with substantial impact in the anti-microbicidal activity and pro-inflammatory cytokine secretion of macrophages. The inflammasome activation in macrophages is dependent on mROS production and mitochondrial regulation and mitochondrial dynamics and functionality direct impact inflammatory responses. Alternative activated macrophage metabolism relies on fatty acid oxidation, and the mechanism responsible for this phenotype is not fully elucidated. Thus, cellular metabolism and mitochondria function is a key immunoregulatory feature of macrophage biology. In this review, we will provide insights into recently reported evidences of mitochondria-related metabolic nodes, which are important for macrophage physiology.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 15%
Student > Bachelor 6 15%
Student > Master 6 15%
Researcher 4 10%
Student > Doctoral Student 2 5%
Other 6 15%
Unknown 10 25%
Readers by discipline Count As %
Immunology and Microbiology 10 25%
Biochemistry, Genetics and Molecular Biology 5 13%
Agricultural and Biological Sciences 3 8%
Medicine and Dentistry 3 8%
Neuroscience 2 5%
Other 4 10%
Unknown 13 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2017.
All research outputs
#16,597,003
of 24,417,958 outputs
Outputs from Cell Biology International
#579
of 1,153 outputs
Outputs of similar age
#279,360
of 449,662 outputs
Outputs of similar age from Cell Biology International
#10
of 29 outputs
Altmetric has tracked 24,417,958 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,153 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 449,662 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.