| Title |
Association between brain volumes and HAND in cART-naïve HIV+ individuals from Thailand
|
|---|---|
| Published in |
Journal of NeuroVirology, January 2015
|
| DOI | 10.1007/s13365-014-0309-8 |
| Pubmed ID | |
| Authors |
Jodi M. Heaps, Pasiri Sithinamsuwan, Robert Paul, Sukalaya Lerdlum, Mantana Pothisri, David Clifford, Somporn Tipsuk, Stephanie Catella, Edgar Busovaca, James L. K. Fletcher, Benjamin Raudabaugh, Silvia Ratto-Kim, Victor Valcour, Jintanat Ananworanich, on behalf of the SEARCH 007/011 study groups |
| Abstract |
This study aimed to determine the effects of human immunodeficiency virus (HIV) on brain structure in HIV-infected individuals with and without HIV-associated neurocognitive disorders (HAND). Twenty-nine HIV-uninfected controls, 37 HIV+, treatment-naïve, individuals with HAND (HIV+HAND+; 16 asymptomatic neurocognitive impairment (ANI), 12 mild neurocognitive disorder (MND), and 9 HIV-associated dementia HAD), and 37 HIV+, treatment-naïve, individuals with normal cognitive function (HIV+HAND-) underwent magnetic resonance imaging (MRI) and neuropsychological assessment. The HIV-infected participants had a mean (SD) age of 35 (7) years, mean (interquartile range (IQR)) CD4 count of 221 (83-324), and mean (IQR) log10 plasma viral load of 4.81 (4.39-5.48). Six regions of interest were selected for analyses including total and subcortical gray matter, total white matter, caudate, corpus callosum, and thalamus. The HIV+/HAND+ group exhibited significantly smaller brain volumes compared to the HIV-uninfected group in subcortical gray and total gray matter; however, there were no statistically significant differences in brain volumes between the HIV+HAND+ and HIV+HAND- groups or between HIV+/HAND- and controls. CD4 count at time of combination antiretroviral therapy (cART) initiation was associated with total and subcortical gray matter volumes but not with cognitive measures. Plasma viral load correlated with neuropsychological performance but not brain volumes. The lack of significant differences in brain volumes between HIV+HAND+ and HIV+HAND- suggests that brain atrophy is not a sensitive measure of HAND in subjects without advanced immunosuppression. Alternatively, current HAND diagnostic criteria may not sufficiently distinguish patients based on MRI measures of brain volumes. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 2% |
| Unknown | 51 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 23% |
| Student > Ph. D. Student | 9 | 17% |
| Researcher | 6 | 12% |
| Student > Bachelor | 4 | 8% |
| Student > Postgraduate | 4 | 8% |
| Other | 4 | 8% |
| Unknown | 13 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 27% |
| Psychology | 7 | 13% |
| Nursing and Health Professions | 5 | 10% |
| Neuroscience | 5 | 10% |
| Business, Management and Accounting | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 18 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2016.
All research outputs
#14,208,760
of 22,778,347 outputs
Outputs from Journal of NeuroVirology
#465
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Outputs of similar age
#186,843
of 351,724 outputs
Outputs of similar age from Journal of NeuroVirology
#7
of 24 outputs
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