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Equivalent mismatch negativity deficits across deviant types in early illness schizophrenia-spectrum patients

Overview of attention for article published in Biological Psychology, January 2015
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Title
Equivalent mismatch negativity deficits across deviant types in early illness schizophrenia-spectrum patients
Published in
Biological Psychology, January 2015
DOI 10.1016/j.biopsycho.2015.01.004
Pubmed ID
Authors

Rachel A. Hay, Brian J. Roach, Vinod H. Srihari, Scott W. Woods, Judith M. Ford, Daniel H. Mathalon

Abstract

Neurophysiological abnormalities in auditory deviance processing, as reflected by the mismatch negativity (MMN), have been observed across the course of schizophrenia. Studies in early schizophrenia patients have typically shown varying degrees of MMN amplitude reduction for different deviant types, suggesting that different auditory deviants are uniquely processed and may be differentially affected by duration of illness. To explore this further, we examined the MMN response to 4 auditory deviants (duration, frequency, duration+frequency "double deviant", and intensity) in 24 schizophrenia-spectrum patients early in the illness (ESZ) and 21 healthy controls. ESZ showed significantly reduced MMN relative to healthy controls for all deviant types (p<0.05), with no significant interaction with deviant type. No correlations with clinical symptoms were present (all p's>0.05). These findings support the conclusion that neurophysiological mechanisms underlying processing of auditory deviants are compromised early in illness, and these deficiencies are not specific to the type of deviant presented.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 60 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 17%
Student > Ph. D. Student 9 15%
Researcher 9 15%
Student > Master 9 15%
Student > Postgraduate 4 7%
Other 7 12%
Unknown 12 20%
Readers by discipline Count As %
Psychology 19 32%
Neuroscience 10 17%
Medicine and Dentistry 10 17%
Agricultural and Biological Sciences 2 3%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 3 5%
Unknown 15 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2015.
All research outputs
#19,942,887
of 25,373,627 outputs
Outputs from Biological Psychology
#1,397
of 1,805 outputs
Outputs of similar age
#253,013
of 359,700 outputs
Outputs of similar age from Biological Psychology
#20
of 28 outputs
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