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Mendeley readers
Attention Score in Context
| Title |
Cyclins D2 and D1 Are Essential for Postnatal Pancreatic β-Cell Growth
|
|---|---|
| Published in |
Molecular & Cellular Biology, March 2023
|
| DOI | 10.1128/mcb.25.9.3752-3762.2005 |
| Pubmed ID | |
| Authors |
Jake A. Kushner, Maria A. Ciemerych, Ewa Sicinska, Lynn M. Wartschow, Monica Teta, Simon Y. Long, Piotr Sicinski, Morris F. White |
| Abstract |
Regulation of adult beta-cell mass in pancreatic islets is essential to preserve sufficient insulin secretion in order to appropriately regulate glucose homeostasis. In many tissues mitogens influence development by stimulating D-type cyclins (D1, D2, or D3) and activating cyclin-dependent kinases (CDK4 or CDK6), which results in progression through the G(1) phase of the cell cycle. Here we show that cyclins D2 and D1 are essential for normal postnatal islet growth. In adult murine islets basal cyclin D2 mRNA expression was easily detected, while cyclin D1 was expressed at lower levels and cyclin D3 was nearly undetectable. Prenatal islet development occurred normally in cyclin D2(-/-) or cyclin D1(+/-) D2(-/-) mice. However, beta-cell proliferation, adult mass, and glucose tolerance were decreased in adult cyclin D2(-/-) mice, causing glucose intolerance that progressed to diabetes by 12 months of age. Although cyclin D1(+/-) mice never developed diabetes, life-threatening diabetes developed in 3-month-old cyclin D1(-/+) D2(-/-) mice as beta-cell mass decreased after birth. Thus, cyclins D2 and D1 were essential for beta-cell expansion in adult mice. Strategies to tightly regulate D-type cyclin activity in beta cells could prevent or cure diabetes. |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Spain | 1 | <1% |
| Netherlands | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 112 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 26% |
| Researcher | 22 | 19% |
| Student > Bachelor | 19 | 16% |
| Student > Master | 11 | 9% |
| Professor > Associate Professor | 7 | 6% |
| Other | 15 | 13% |
| Unknown | 12 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 45 | 38% |
| Biochemistry, Genetics and Molecular Biology | 32 | 27% |
| Medicine and Dentistry | 17 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Engineering | 2 | 2% |
| Other | 4 | 3% |
| Unknown | 14 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2017.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from Molecular & Cellular Biology
#4,291
of 11,892 outputs
Outputs of similar age
#150,109
of 421,553 outputs
Outputs of similar age from Molecular & Cellular Biology
#3,243
of 8,975 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,892 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,553 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 8,975 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.