Title |
Hope vs hype: where are we in type 1 diabetes?
|
---|---|
Published in |
Diabetologia, December 2017
|
DOI | 10.1007/s00125-017-4530-x |
Pubmed ID | |
Authors |
Jay S. Skyler |
Abstract |
Much progress has been made in type 1 diabetes research. Biological replacement of islet function has been achieved with pancreas transplantation and with islet transplantation. In the future, human embryonic stem cells and/or induced pluripotent stem cells may offer a potentially unlimited source of cells for islet replacement. Another potential strategy is to induce robust beta cell replication so that regeneration of islets can be achieved. Immune interventions are being studied with the hope of arresting the type 1 diabetes disease process to either prevent the disease or help preserve beta cell function. Mechanical replacement of islet cell function involves the use of glucose sensor-controlled insulin infusion systems. As all of these avenues are pursued, headlines often overstate the case, thus hyping any given advance, which provides enormous hope for patients and families seeking a cure for type 1 diabetes. Often, however, it is an animal study or a pilot trial that is being described. The reality is that translation to successful trials in human beings may not be readily achievable. This article discusses both the hype and the hopes in type 1 diabetes research. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 9 | 18% |
Spain | 5 | 10% |
United States | 4 | 8% |
Canada | 4 | 8% |
Australia | 3 | 6% |
Denmark | 2 | 4% |
Germany | 2 | 4% |
Austria | 1 | 2% |
Netherlands | 1 | 2% |
Other | 4 | 8% |
Unknown | 15 | 30% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 27 | 54% |
Scientists | 14 | 28% |
Practitioners (doctors, other healthcare professionals) | 8 | 16% |
Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 119 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 16 | 13% |
Student > Ph. D. Student | 15 | 13% |
Student > Master | 15 | 13% |
Student > Bachelor | 11 | 9% |
Student > Doctoral Student | 8 | 7% |
Other | 19 | 16% |
Unknown | 35 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 29 | 24% |
Biochemistry, Genetics and Molecular Biology | 21 | 18% |
Agricultural and Biological Sciences | 6 | 5% |
Immunology and Microbiology | 5 | 4% |
Engineering | 4 | 3% |
Other | 15 | 13% |
Unknown | 39 | 33% |