| Title |
The Photodynamic Effect of Different Size ZnO Nanoparticles on Cancer Cell Proliferation In Vitro
|
|---|---|
| Published in |
Discover Nano, April 2010
|
| DOI | 10.1007/s11671-010-9603-4 |
| Pubmed ID | |
| Authors |
Jingyuan Li, Dadong Guo, Xuemei Wang, Huangping Wang, Hui Jiang, Baoan Chen |
| Abstract |
Nanomaterials have widely been used in the field of biological and biomedicine, such as tissue imaging, diagnosis and cancer therapy. In this study, we explored the cytotoxicity and photodynamic effect of different-sized ZnO nanoparticles to target cells. Our observations demonstrated that ZnO nanoparticles exerted dose-dependent and time-dependent cytotoxicity for cancer cells like hepatocellular carcinoma SMMC-7721 cells in vitro. Meanwhile, it was observed that UV irradiation could enhance the suppression ability of ZnO nanoparticles on cancer cells proliferation, and these effects were in the size-dependent manner. Furthermore, when ZnO nanoparticles combined with daunorubicin, the related cytotoxicity of anticancer agents on cancer cells was evidently enhanced, suggesting that ZnO nanoparticles could play an important role in drug delivery. This may offer the possibility of the great potential and promising applications of the ZnO nanoparticles in clinical and biomedical areas like photodynamic cancer therapy and others. |
Mendeley readers
The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 3 | 2% |
| United States | 3 | 2% |
| Denmark | 1 | <1% |
| Pakistan | 1 | <1% |
| Unknown | 141 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 20% |
| Student > Master | 25 | 17% |
| Researcher | 24 | 16% |
| Student > Doctoral Student | 9 | 6% |
| Student > Bachelor | 9 | 6% |
| Other | 23 | 15% |
| Unknown | 29 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 27 | 18% |
| Agricultural and Biological Sciences | 24 | 16% |
| Physics and Astronomy | 16 | 11% |
| Biochemistry, Genetics and Molecular Biology | 11 | 7% |
| Materials Science | 11 | 7% |
| Other | 24 | 16% |
| Unknown | 36 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2015.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Discover Nano
#798
of 1,146 outputs
Outputs of similar age
#88,233
of 92,242 outputs
Outputs of similar age from Discover Nano
#14
of 14 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,146 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 92,242 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.