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The Long Noncoding RNA OIP5-AS1 Is Involved in the Regulation of Cell Proliferation.

Overview of attention for article published in Anticancer Research: International Journal of Cancer Research and Treatment, January 2018
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Title
The Long Noncoding RNA OIP5-AS1 Is Involved in the Regulation of Cell Proliferation.
Published in
Anticancer Research: International Journal of Cancer Research and Treatment, January 2018
DOI 10.21873/anticanres.12194
Pubmed ID
Authors

Madoka Naemura, Masahide Kuroki, Toshiyuki Tsunoda, Nagisa Arikawa, Yuuga Sawata, Senji Shirasawa, Yojiro Kotake

Abstract

OPA-interacting protein 5 antisense transcript 1 (OIP5-AS1) is a long noncoding RNA located on human chromosome 15q15.1 and transcribed in the opposite direction to OIP5. Here, we report that OIP5-AS1 is involved in regulating cell proliferation. HeLa cells were transfected with OIP5-AS1-targeting siRNA oligonucleotides and anti-sense oligonucleotides. The cells were harvested 72 h after transfection and subjected to quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and cell-cycle and apoptosis analysis. OIP5-AS1 was expressed at a lower level in cells harbouring an oncogenic kirsten rat sarcoma viral oncogene homolog (K-RAS) mutation than in cells expressing wild-type K-RAS. Silencing OIP5-AS1 with siRNA oligonucleotides or anti-sense oligonucleotides reduced HeLa cell proliferation. Apoptosis and cell-cycle analysis showed that silencing OIP5-AS1 did not cause apoptosis, but did cause G2/M phase cell-cycle arrest. These results suggest that OIP5-AS1 positively regulates cell proliferation by promoting G2/M phase progression.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 22%
Student > Bachelor 2 22%
Student > Ph. D. Student 1 11%
Researcher 1 11%
Professor > Associate Professor 1 11%
Other 0 0%
Unknown 2 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 44%
Agricultural and Biological Sciences 2 22%
Medicine and Dentistry 1 11%
Unknown 2 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2018.
All research outputs
#15,989,045
of 25,382,440 outputs
Outputs from Anticancer Research: International Journal of Cancer Research and Treatment
#1,219
of 4,016 outputs
Outputs of similar age
#253,701
of 449,549 outputs
Outputs of similar age from Anticancer Research: International Journal of Cancer Research and Treatment
#31
of 104 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,016 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 449,549 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 104 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.