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Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia

Overview of attention for article published in Schizophrenia Research, August 2005
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

blogs
1 blog
facebook
1 Facebook page

Citations

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194 Dimensions

Readers on

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84 Mendeley
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Title
Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia
Published in
Schizophrenia Research, August 2005
DOI 10.1016/j.schres.2005.07.013
Pubmed ID
Authors

L.K. Nilsson, K.R. Linderholm, G. Engberg, L. Paulson, K. Blennow, L.H. Lindström, C. Nordin, A. Karanti, P. Persson, S. Erhardt

Abstract

Previous studies have shown that endogenous brain levels of kynurenic acid (KYNA), a glutamate receptor antagonist, are elevated in patients with schizophrenia. Here we analyse KYNA in the cerebrospinal fluid (CSF) from a large cohort, including male healthy controls (n=49) and male patients with schizophrenia (n=90). We found that male patients with schizophrenia had significantly higher levels of CSF KYNA compared to healthy male controls (1.45 nM+/-0.10 vs. 1.06 nM+/-0.06 in the control group). Furthermore, when the patients with schizophrenia were divided into subgroups we found that CSF KYNA levels were significantly elevated in drug-naïve, first episode patients (1.53 nM+/-0.19, n=37) and in patients undergoing treatment with antipsychotic drugs (1.53 nM+/-0.17, n=34) compared to healthy male controls. No elevated CSF KYNA levels were detected in drug-free patients with schizophrenia, i.e. patients previously undergoing antipsychotic medications but drug-free at time of sampling (1.16 nM+/-0.10, n=19). Present results confirm that CSF KYNA concentration is elevated in patients with schizophrenia and are consistent with the hypothesis that KYNA contributes to the pathophysiology of the disease.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 4%
Hungary 1 1%
Unknown 80 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 33%
Researcher 12 14%
Student > Master 9 11%
Student > Bachelor 6 7%
Professor 4 5%
Other 12 14%
Unknown 13 15%
Readers by discipline Count As %
Medicine and Dentistry 21 25%
Neuroscience 14 17%
Agricultural and Biological Sciences 12 14%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Biochemistry, Genetics and Molecular Biology 4 5%
Other 11 13%
Unknown 18 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2015.
All research outputs
#6,322,824
of 25,373,627 outputs
Outputs from Schizophrenia Research
#1,557
of 5,686 outputs
Outputs of similar age
#20,536
of 68,826 outputs
Outputs of similar age from Schizophrenia Research
#11
of 32 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,686 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 68,826 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.