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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Rad51 supports triple negative breast cancer metastasis.
|
|---|---|
| Published in |
Oncotarget, April 2014
|
| DOI | 10.18632/oncotarget.1923 |
| Pubmed ID | |
| Authors |
Adrian P Wiegmans, Fares Al-Ejeh, Nicole Chee, Pei-Yi Yap, Julia J Gorski, Leonard Da Silva, Emma Bolderson, Georgia Chenevix-Trench, Robin Anderson, Peter T Simpson, Sunil R Lakhani, Kum Kum Khanna |
| Abstract |
In contrast to extensive studies on familial breast cancer, it is currently unclear whether defects in DNA double strand break (DSB) repair genes play a role in sporadic breast cancer development and progression. We performed analysis of immunohistochemistry in an independent cohort of 235 were sporadic breast tumours. This analysis suggested that RAD51 expression is increased during breast cancer progression and metastasis and an oncogenic role for RAD51 when deregulated. Subsequent knockdown of RAD51 repressed cancer cell migration in vitro and reduced primary tumor growth in a syngeneic mouse model in vivo. Loss of RAD51 also inhibited associated metastasis not only in syngeneic mice but human xenografts and changed the metastatic gene expression profile of cancer cells, consistent with inhibition of distant metastasis. This demonstrates for the first time a new function of RAD51 that may underlie the proclivity of patients with RAD51 overexpression to develop distant metastasis. RAD51 is a potential biomarker and attractive drug target for metastatic triple negative breast cancer, with the capability to extend the survival of patients, which is less than 6 months. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 65 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 11 | 17% |
| Student > Master | 10 | 15% |
| Researcher | 9 | 14% |
| Student > Ph. D. Student | 8 | 12% |
| Student > Doctoral Student | 2 | 3% |
| Other | 10 | 15% |
| Unknown | 15 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 31% |
| Agricultural and Biological Sciences | 12 | 18% |
| Medicine and Dentistry | 8 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Mathematics | 1 | 2% |
| Other | 4 | 6% |
| Unknown | 18 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2023.
All research outputs
#7,091,541
of 24,657,405 outputs
Outputs from Oncotarget
#3,149
of 14,197 outputs
Outputs of similar age
#63,781
of 231,763 outputs
Outputs of similar age from Oncotarget
#37
of 143 outputs
Altmetric has tracked 24,657,405 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 14,197 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,763 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 143 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.