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G protein-coupled receptors in cardiac biology: old and new receptors

Overview of attention for article published in Biophysical Reviews, January 2015
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Title
G protein-coupled receptors in cardiac biology: old and new receptors
Published in
Biophysical Reviews, January 2015
DOI 10.1007/s12551-014-0154-2
Pubmed ID
Authors

Simon R. Foster, Eugeni Roura, Peter Molenaar, Walter G. Thomas

Abstract

G protein-coupled receptors (GPCRs) are seven-transmembrane-spanning proteins that mediate cellular and physiological responses. They are critical for cardiovascular function and are targeted for the treatment of hypertension and heart failure. Nevertheless, current therapies only target a small fraction of the cardiac GPCR repertoire, indicating that there are many opportunities to investigate unappreciated aspects of heart biology. Here, we offer an update on the contemporary view of GPCRs and the complexities of their signalling, and review the roles of the 'classical' GPCRs in cardiovascular physiology and disease. We then provide insights into other GPCRs that have been less extensively studied in the heart, including orphan, odorant and taste receptors. We contend that these novel cardiac GPCRs contribute to heart function in health and disease and thereby offer exciting opportunities to therapeutically modulate heart function.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 2%
Unknown 49 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 15 30%
Student > Ph. D. Student 9 18%
Researcher 7 14%
Student > Doctoral Student 2 4%
Other 2 4%
Other 6 12%
Unknown 9 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 28%
Agricultural and Biological Sciences 9 18%
Pharmacology, Toxicology and Pharmaceutical Science 6 12%
Medicine and Dentistry 4 8%
Neuroscience 3 6%
Other 6 12%
Unknown 8 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2015.
All research outputs
#20,251,039
of 22,780,165 outputs
Outputs from Biophysical Reviews
#699
of 794 outputs
Outputs of similar age
#296,269
of 353,089 outputs
Outputs of similar age from Biophysical Reviews
#10
of 22 outputs
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So far Altmetric has tracked 794 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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