↓ Skip to main content

Orally-dissolving film for sublingual and buccal delivery of ropinirole

Overview of attention for article published in Colloids & Surfaces B: Biointerfaces, December 2017
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
1 X user
facebook
2 Facebook pages

Citations

dimensions_citation
51 Dimensions

Readers on

mendeley
107 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Orally-dissolving film for sublingual and buccal delivery of ropinirole
Published in
Colloids & Surfaces B: Biointerfaces, December 2017
DOI 10.1016/j.colsurfb.2017.12.015
Pubmed ID
Authors

Ka Lun Lai, Yuan Fang, Hao Han, Qingqing Li, Shuai Zhang, Ho Yin Li, Shing Fung Chow, Tai Ning Lam, Wai Yip Thomas Lee

Abstract

Ropinirole is a very important treatment option for Parkinson's disease (PD), a major threat to the aging population. However, this drug undergoes extensive first-pass metabolism, resulting in a low oral bioavailability. Moreover, the necessity of frequent administration due to the short half-life of ropinirole may jeopardize patient compliance. Indeed, taking this drug in solid oral dosage forms (e.g. Tablet) can be a challenge because of the tremor, rigidity, limited mobility, and impaired drug absorption experienced by PD patients. In light of these, there is a pressing need to devise formulations for the delivery of ropinirole that allow simple and easy administration and fast drug action, as well as avoidance of first-pass metabolism and overcoming the challenge of impaired absorption due to gastrointestinal dysfunctions, etc. Herein, we seek to overcome all these challenges via sublingual or buccal delivery of orally-dissolving films. Accordingly, we aimed to fabricate and characterize orally-dissolving films of ropinirole and assess their in vivo pharmacokinetics after sublingual and buccal administration. The ropinirole oral film was non-toxic and exhibited fast disintegration and dissolution and was physically stable for at least 28 days. Upon buccal/sublingual administration of the oral films, ropinirole reached the systemic circulation within 15 min and bioavailability was significantly improved, which may be attributable to avoidance of first-pass metabolism via absorption through the oral cavity. In conclusion, our ropinirole oral film improved bioavailability after sublingual or buccal administration. This formulation potentially overcomes biopharmaceutical challenges and provide a convenient means of administration of ropinirole or other anti-PD drugs.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 107 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 17%
Student > Bachelor 16 15%
Student > Master 15 14%
Researcher 7 7%
Student > Doctoral Student 3 3%
Other 10 9%
Unknown 38 36%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 33 31%
Medicine and Dentistry 7 7%
Neuroscience 4 4%
Engineering 4 4%
Materials Science 2 2%
Other 9 8%
Unknown 48 45%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2017.
All research outputs
#17,292,294
of 25,382,440 outputs
Outputs from Colloids & Surfaces B: Biointerfaces
#1,875
of 3,088 outputs
Outputs of similar age
#278,669
of 443,420 outputs
Outputs of similar age from Colloids & Surfaces B: Biointerfaces
#17
of 40 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,088 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 443,420 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.