| Title |
Folate-Targeted Multifunctional Amino Acid-Chitosan Nanoparticles for Improved Cancer Therapy
|
|---|---|
| Published in |
Pharmaceutical Research, September 2014
|
| DOI | 10.1007/s11095-014-1486-0 |
| Pubmed ID | |
| Authors |
Vítor M. Gaspar, Elisabete C. Costa, João A. Queiroz, Chantal Pichon, Fani Sousa, Ilídio J. Correia |
| Abstract |
Tumor targeting nanomaterials have potential for improving the efficiency of anti-tumoral therapeutics. However, the evaluation of their biological performance remains highly challenging. In this study we describe the synthesis of multifunctional nanoparticles decorated with folic acid-PEG and dual amino acid-modified chitosan (CM-PFA) complexed with DNA and their evaluation in organotypic 2D co-cultures of cancer-normal cells and also on 3D multicellular tumor spheroids models. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Portugal | 1 | 1% |
| Unknown | 68 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 24% |
| Student > Bachelor | 9 | 13% |
| Researcher | 8 | 11% |
| Student > Master | 5 | 7% |
| Student > Doctoral Student | 3 | 4% |
| Other | 13 | 19% |
| Unknown | 15 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 21% |
| Chemistry | 7 | 10% |
| Biochemistry, Genetics and Molecular Biology | 6 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
| Medicine and Dentistry | 5 | 7% |
| Other | 9 | 13% |
| Unknown | 23 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2015.
All research outputs
#14,667,077
of 22,780,165 outputs
Outputs from Pharmaceutical Research
#2,186
of 2,856 outputs
Outputs of similar age
#128,707
of 237,922 outputs
Outputs of similar age from Pharmaceutical Research
#17
of 35 outputs
Altmetric has tracked 22,780,165 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,856 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,922 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.