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Mendeley readers
Attention Score in Context
| Title |
Biologic effects induced in vitro by PM10 from three different zones of Mexico City.
|
|---|---|
| Published in |
EHP toxicogenomics journal of the National Institute of Environmental Health Sciences, July 2002
|
| DOI | 10.1289/ehp.02110715 |
| Pubmed ID | |
| Authors |
Ernesto Alfaro-Moreno, Leticia Martínez, Claudia García-Cuellar, James C Bonner, J Clifford Murray, Irma Rosas, Sergio Ponce de León Rosales, Alvaro R Osornio-Vargas |
| Abstract |
Exposure to urban airborne particles is associated with an increase in morbidity and mortality. There is little experimental evidence of the mechanisms involved and the role of particle composition. We assessed cytotoxicity (crystal violet assay), apoptosis [terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) or annexin V assay], DNA breakage (comet assay), and production of proinflammatory mediators [tumor necrosis factor Alpha (TNF-Alpha), interleukin 6 (IL-6), prostaglandin E2 (PGE2)] (enzyme-linked immunosorbent assay), and E-selectin (flow cytometry) in cell lines exposed to particulate matter < 10 microm in size (PM10) obtained from the northern, central, and southern zones of Mexico City. Particle concentrations ranged from 2.5 to 160 microg/cm(2). We used epithelial, endothelial, fibroblastic, and monocytic cells and assessed DNA damage in Balb-c cells, TNF-Alpha and IL-6 production in mouse monocytes, and PGE2 in rat lung fibroblasts. We determined the expression of E-selectin in human endothelial cells and evaluated the cytotoxic potential of the PM10 samples in all cell types. PM10 from all three zones of Mexico City caused cell death, DNA breakage, and apoptosis, with particles from the north and central zones being the most toxic. All of these PM10 samples induced secretion of proinflammatory molecules, and particles from the central zone were the most potent. Endothelial cells exposed to PM10 from the three zones expressed similar E-selectin levels. Mexico City PM10 induced biologic effects dependent on the zone of origin, which could be caused by differences in the mixture or size distribution within particle samples. Our data suggest that particle composition as well as particle size should be considered in assessing the adverse effects of airborne particulate pollution. |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 1% |
| United States | 1 | 1% |
| Belgium | 1 | 1% |
| Australia | 1 | 1% |
| Unknown | 76 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 21% |
| Student > Master | 11 | 14% |
| Researcher | 10 | 13% |
| Student > Bachelor | 9 | 11% |
| Professor | 5 | 6% |
| Other | 15 | 19% |
| Unknown | 13 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Environmental Science | 16 | 20% |
| Agricultural and Biological Sciences | 11 | 14% |
| Medicine and Dentistry | 8 | 10% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Chemistry | 5 | 6% |
| Other | 15 | 19% |
| Unknown | 18 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2019.
All research outputs
#8,535,684
of 25,377,790 outputs
Outputs from EHP toxicogenomics journal of the National Institute of Environmental Health Sciences
#5,161
of 8,404 outputs
Outputs of similar age
#16,876
of 47,904 outputs
Outputs of similar age from EHP toxicogenomics journal of the National Institute of Environmental Health Sciences
#49
of 75 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,404 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.4. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 47,904 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.