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The potential therapeutic effects of ergothioneine in pre-eclampsia

Overview of attention for article published in Free Radical Biology & Medicine, December 2017
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  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

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Title
The potential therapeutic effects of ergothioneine in pre-eclampsia
Published in
Free Radical Biology & Medicine, December 2017
DOI 10.1016/j.freeradbiomed.2017.12.030
Pubmed ID
Authors

Robert N Kerley, Cathal McCarthy, Douglas B Kell, Louise C Kenny

Abstract

Ergothioneine (ERG), is a water-soluble amino acid that is derived entirely from dietary sources. It has received much attention as a therapeutic agent due to its anti-oxidant properties, and there are claims of preferential accumulation within high oxidative stress organs. Pre-eclampsia, a condition accompanied by increased oxidative stress, is one of the leading causes of maternal morbidity and mortality. Despite intense research efforts, its aetiologies remain somewhat unclear and there are still no effective treatment options. Clinical trials of the anti-oxidants vitamin C and vitamin E have proven largely ineffective with little improvement in clinical outcome or even a negative response. This could be explained in part by their inability to permeate the plasma and mitochondrial membranes and scavenge mitochondria-derived superoxide species, and for the former by the fact that it is actually a pro-oxidant in the presence of unliganded iron. ERG accumulates within tissues through the action of a specific organic cation transporter, SLC22A4 (previously referred to as OCTN1), which is possibly also expressed in mammalian mitochondria. Mitochondrial dysfunction has been implicated in a variety of vascular diseases including pre-eclampsia. This review discusses the use of ERG as a possibly mitochondrial-targeted anti-oxidant, focusing on its physical properties, potential mechanisms of action, safety profile and administration in relation to pregnancies complicated by pre-eclampsia.

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X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 83 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 16%
Student > Ph. D. Student 12 14%
Student > Bachelor 12 14%
Student > Master 6 7%
Other 4 5%
Other 13 16%
Unknown 23 28%
Readers by discipline Count As %
Medicine and Dentistry 12 14%
Biochemistry, Genetics and Molecular Biology 9 11%
Agricultural and Biological Sciences 9 11%
Nursing and Health Professions 5 6%
Chemistry 5 6%
Other 13 16%
Unknown 30 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2022.
All research outputs
#6,531,102
of 25,483,400 outputs
Outputs from Free Radical Biology & Medicine
#1,457
of 5,451 outputs
Outputs of similar age
#119,026
of 449,572 outputs
Outputs of similar age from Free Radical Biology & Medicine
#11
of 73 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 5,451 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 449,572 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.