Title |
Aged Human Multipotent Mesenchymal Stromal Cells Can Be Rejuvenated by Neuron-Derived Neurotrophic Factor and Improve Heart Function After Injury
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Published in |
JACC: Basic to Translational Science, November 2017
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DOI | 10.1016/j.jacbts.2017.07.014 |
Pubmed ID | |
Authors |
Hui-Fang Song, Sheng He, Shu-Hong Li, Wen-Juan Yin, Jun Wu, Jian Guo, Zheng-Bo Shao, Xiao-Yan Zhai, Hui Gong, Li Lu, Fang Wei, Richard D. Weisel, Jun Xie, Ren-Ke Li |
Abstract |
Reduced regenerative capacity of aged stem cells hampers the benefits of autologous cell therapy for cardiac regeneration. This study investigated whether neuron-derived neurotrophic factor (NDNF) could rejuvenate aged human bone marrow (hBM)- multipotent mesenchymal stromal cells (MSCs) and whether the rejuvenated hBM-MSCs could improve cardiac repair after ischemic injury. Over-expression of NDNF in old hBM-MSCs decreased cell senescence and apoptosis. Engraftment of NDNF over-expressing old hBM-MSCs into the ischemic area of mouse hearts resulted in improved cardiac function after myocardial infarction, while promoting implanted stem cell survival. Our findings suggest NDNF could be a new factor to rejuvenate aged stem cells and improve their capability to repair the aged heart after injury. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 27% |
Australia | 1 | 7% |
Croatia | 1 | 7% |
Nigeria | 1 | 7% |
Peru | 1 | 7% |
Spain | 1 | 7% |
Unknown | 6 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 9 | 60% |
Practitioners (doctors, other healthcare professionals) | 3 | 20% |
Science communicators (journalists, bloggers, editors) | 2 | 13% |
Scientists | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 5 | 20% |
Student > Bachelor | 2 | 8% |
Student > Ph. D. Student | 2 | 8% |
Professor | 2 | 8% |
Researcher | 2 | 8% |
Other | 2 | 8% |
Unknown | 10 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 28% |
Medicine and Dentistry | 3 | 12% |
Neuroscience | 1 | 4% |
Agricultural and Biological Sciences | 1 | 4% |
Unknown | 13 | 52% |