| Title |
New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1
|
|---|---|
| Published in |
Journal of Natural Medicines, December 2017
|
| DOI | 10.1007/s11418-017-1166-6 |
| Pubmed ID | |
| Authors |
Keiko Ogawa, Seikou Nakamura, Kohei Hosokawa, Hanako Ishimaru, Natsuki Saito, Kaori Ryu, Masahiro Fujimuro, Souichi Nakashima, Hisashi Matsuda |
| Abstract |
Nigella species are rich source of dolabellane diterpenes. During our study of Nigella species, new dolabellane diterpenes, damasterpenes V-VIII were isolated. The structural determination of new compounds damasterpenes V-VIII is described with consideration of their absolute configurations. The antiviral activities against herpes simplex virus type-1 of the isolated compounds and their derivatives are also evaluated. Damasterpene V (inhibition 35.0%) and 2-phenylacetyl 13-benzoyl damasterpenol (32.0%) showed significant antiviral activity at 10 μM. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 20 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 15% |
| Student > Bachelor | 2 | 10% |
| Student > Ph. D. Student | 1 | 5% |
| Student > Doctoral Student | 1 | 5% |
| Student > Master | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 11 | 55% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 15% |
| Chemistry | 2 | 10% |
| Biochemistry, Genetics and Molecular Biology | 1 | 5% |
| Unknown | 14 | 70% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2017.
All research outputs
#18,581,651
of 23,015,156 outputs
Outputs from Journal of Natural Medicines
#303
of 533 outputs
Outputs of similar age
#329,955
of 441,864 outputs
Outputs of similar age from Journal of Natural Medicines
#14
of 24 outputs
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