Title |
Dimorphic Effects of Transforming Growth Factor-&bgr; Signaling During Aortic Aneurysm Progression in Mice Suggest a Combinatorial Therapy for Marfan Syndrome
|
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Published in |
Arteriosclerosis, Thrombosis, and Vascular Biology (Highwire), January 2015
|
DOI | 10.1161/atvbaha.114.305150 |
Pubmed ID | |
Authors |
Jason R Cook, Nicholas P Clayton, Luca Carta, Josephine Galatioto, Emily Chiu, Silvia Smaldone, Carol A Nelson, Seng H Cheng, Bruce M Wentworth, Francesco Ramirez |
Abstract |
Studies of mice with mild Marfan syndrome (MFS) have correlated the development of thoracic aortic aneurysm (TAA) with improper stimulation of noncanonical (Erk-mediated) TGFβ signaling by the angiotensin type I receptor (AT1r). This correlation was largely based on comparable TAA modifications by either systemic TGFβ neutralization or AT1r antagonism. However, subsequent investigations have called into question some key aspects of this mechanism of arterial disease in MFS. To resolve these controversial points, here we made a head-to-head comparison of the therapeutic benefits of TGFβ neutralization and AT1r antagonism in mice with progressively severe MFS (Fbn1(mgR/mgR) mice). |
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Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 2% |
Israel | 1 | <1% |
New Zealand | 1 | <1% |
Russia | 1 | <1% |
Unknown | 101 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 20 | 19% |
Researcher | 19 | 18% |
Student > Master | 14 | 13% |
Student > Bachelor | 12 | 11% |
Student > Doctoral Student | 6 | 6% |
Other | 12 | 11% |
Unknown | 23 | 22% |
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Agricultural and Biological Sciences | 18 | 17% |
Engineering | 6 | 6% |
Nursing and Health Professions | 3 | 3% |
Other | 5 | 5% |
Unknown | 30 | 28% |