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Dimorphic Effects of Transforming Growth Factor-&bgr; Signaling During Aortic Aneurysm Progression in Mice Suggest a Combinatorial Therapy for Marfan Syndrome

Overview of attention for article published in Arteriosclerosis, Thrombosis, and Vascular Biology (Highwire), January 2015
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  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

twitter
2 X users
patent
1 patent
facebook
1 Facebook page

Citations

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191 Dimensions

Readers on

mendeley
106 Mendeley
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Title
Dimorphic Effects of Transforming Growth Factor-&bgr; Signaling During Aortic Aneurysm Progression in Mice Suggest a Combinatorial Therapy for Marfan Syndrome
Published in
Arteriosclerosis, Thrombosis, and Vascular Biology (Highwire), January 2015
DOI 10.1161/atvbaha.114.305150
Pubmed ID
Authors

Jason R Cook, Nicholas P Clayton, Luca Carta, Josephine Galatioto, Emily Chiu, Silvia Smaldone, Carol A Nelson, Seng H Cheng, Bruce M Wentworth, Francesco Ramirez

Abstract

Studies of mice with mild Marfan syndrome (MFS) have correlated the development of thoracic aortic aneurysm (TAA) with improper stimulation of noncanonical (Erk-mediated) TGFβ signaling by the angiotensin type I receptor (AT1r). This correlation was largely based on comparable TAA modifications by either systemic TGFβ neutralization or AT1r antagonism. However, subsequent investigations have called into question some key aspects of this mechanism of arterial disease in MFS. To resolve these controversial points, here we made a head-to-head comparison of the therapeutic benefits of TGFβ neutralization and AT1r antagonism in mice with progressively severe MFS (Fbn1(mgR/mgR) mice).

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Israel 1 <1%
New Zealand 1 <1%
Russia 1 <1%
Unknown 101 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 19%
Researcher 19 18%
Student > Master 14 13%
Student > Bachelor 12 11%
Student > Doctoral Student 6 6%
Other 12 11%
Unknown 23 22%
Readers by discipline Count As %
Medicine and Dentistry 25 24%
Biochemistry, Genetics and Molecular Biology 19 18%
Agricultural and Biological Sciences 18 17%
Engineering 6 6%
Nursing and Health Professions 3 3%
Other 5 5%
Unknown 30 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2023.
All research outputs
#7,205,295
of 25,374,647 outputs
Outputs from Arteriosclerosis, Thrombosis, and Vascular Biology (Highwire)
#2,098
of 6,069 outputs
Outputs of similar age
#90,763
of 359,659 outputs
Outputs of similar age from Arteriosclerosis, Thrombosis, and Vascular Biology (Highwire)
#14
of 89 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 6,069 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,659 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.