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Newly Generated CD4+ T Cells Acquire Metabolic Quiescence after Thymic Egress

Overview of attention for article published in The Journal of Immunology, February 2018
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Title
Newly Generated CD4+ T Cells Acquire Metabolic Quiescence after Thymic Egress
Published in
The Journal of Immunology, February 2018
DOI 10.4049/jimmunol.1700721
Pubmed ID
Authors

Shusong Zhang, Xinwei Zhang, Ke Wang, Xi Xu, Mingyang Li, Jun Zhang, Yan Zhang, Jie Hao, Xiuyuan Sun, Yingyu Chen, Xiaohui Liu, Yingjun Chang, Rong Jin, Hounan Wu, Qing Ge

Abstract

Mature naive T cells circulate through the secondary lymphoid organs in an actively enforced quiescent state. Impaired cell survival and cell functions could be found when T cells have defects in quiescence. One of the key features of T cell quiescence is low basal metabolic activity. It remains unclear at which developmental stage T cells acquire this metabolic quiescence. We compared mitochondria among CD4 single-positive (SP) T cells in the thymus, CD4+ recent thymic emigrants (RTEs), and mature naive T cells in the periphery. The results demonstrate that RTEs and naive T cells had reduced mitochondrial content and mitochondrial reactive oxygen species when compared with SP thymocytes. This downregulation of mitochondria requires T cell egress from the thymus and occurs early after young T cells enter the circulation. Autophagic clearance of mitochondria, but not mitochondria biogenesis or fission/fusion, contributes to mitochondrial downregulation in RTEs. The enhanced apoptosis signal-regulating kinase 1/MAPKs and reduced mechanistic target of rapamycin activities in RTEs relative to SP thymocytes may be involved in this mitochondrial reduction. These results indicate that the gain of metabolic quiescence is one of the important maturation processes during SP-RTE transition. Together with functional maturation, it promotes the survival and full responsiveness to activating stimuli in young T cells.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 19%
Researcher 5 12%
Student > Master 4 10%
Student > Bachelor 3 7%
Other 3 7%
Other 8 19%
Unknown 11 26%
Readers by discipline Count As %
Immunology and Microbiology 15 36%
Biochemistry, Genetics and Molecular Biology 6 14%
Agricultural and Biological Sciences 4 10%
Medicine and Dentistry 2 5%
Unspecified 1 2%
Other 2 5%
Unknown 12 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2018.
All research outputs
#19,015,492
of 23,567,572 outputs
Outputs from The Journal of Immunology
#26,272
of 27,977 outputs
Outputs of similar age
#332,713
of 442,605 outputs
Outputs of similar age from The Journal of Immunology
#178
of 194 outputs
Altmetric has tracked 23,567,572 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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