| Title |
Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model
|
|---|---|
| Published in |
Translational Stroke Research, December 2017
|
| DOI | 10.1007/s12975-017-0599-2 |
| Pubmed ID | |
| Authors |
Robin L. Webb, Erin E. Kaiser, Shelley L. Scoville, Tyler A. Thompson, Sumbul Fatima, Chirayukumar Pandya, Karishma Sriram, Raymond L. Swetenburg, Kumar Vaibhav, Ali S. Arbab, Babak Baban, Krishnan M. Dhandapani, David C. Hess, M. N. Hoda, Steven L. Stice |
| Abstract |
Over 700 drugs have failed in stroke clinical trials, an unprecedented rate thought to be attributed in part to limited and isolated testing often solely in "young" rodent models and focusing on a single secondary injury mechanism. Here, extracellular vesicles (EVs), nanometer-sized cell signaling particles, were tested in a mouse thromboembolic (TE) stroke model. Neural stem cell (NSC) and mesenchymal stem cell (MSC) EVs derived from the same pluripotent stem cell (PSC) line were evaluated for changes in infarct volume as well as sensorimotor function. NSC EVs improved cellular, tissue, and functional outcomes in middle-aged rodents, whereas MSC EVs were less effective. Acute differences in lesion volume following NSC EV treatment were corroborated by MRI in 18-month-old aged rodents. NSC EV treatment has a positive effect on motor function in the aged rodent as indicated by beam walk, instances of foot faults, and strength evaluated by hanging wire test. Increased time with a novel object also indicated that NSC EVs improved episodic memory formation in the rodent. The therapeutic effect of NSC EVs appears to be mediated by altering the systemic immune response. These data strongly support further preclinical development of a NSC EV-based stroke therapy and warrant their testing in combination with FDA-approved stroke therapies. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 4 | 13% |
| Canada | 2 | 7% |
| India | 2 | 7% |
| Brazil | 2 | 7% |
| United States | 2 | 7% |
| Australia | 1 | 3% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| South Africa | 1 | 3% |
| United Kingdom | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 13 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 24 | 80% |
| Scientists | 4 | 13% |
| Science communicators (journalists, bloggers, editors) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 186 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 186 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 16% |
| Student > Master | 25 | 13% |
| Student > Bachelor | 24 | 13% |
| Researcher | 19 | 10% |
| Other | 7 | 4% |
| Other | 27 | 15% |
| Unknown | 55 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 16% |
| Neuroscience | 26 | 14% |
| Medicine and Dentistry | 22 | 12% |
| Agricultural and Biological Sciences | 14 | 8% |
| Nursing and Health Professions | 5 | 3% |
| Other | 22 | 12% |
| Unknown | 67 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 158. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2021.
All research outputs
#219,073
of 23,015,156 outputs
Outputs from Translational Stroke Research
#1
of 444 outputs
Outputs of similar age
#5,597
of 441,975 outputs
Outputs of similar age from Translational Stroke Research
#1
of 16 outputs
Altmetric has tracked 23,015,156 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 444 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 441,975 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.